Roles of endothelin-1 and nitric oxide in the mechanism for ethanol-induced vasoconstriction in rat liver

This study was designed to investigate the mechanism for ethanol-induced hepatic vasoconstriction in isolated perfused rat liver. Upon initiation of ethanol infusion into the portal vein at concentrations ranging from 25 to 100 mM, portal pressure began to increase in a concentration-dependent manne...

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Veröffentlicht in:	The Journal of clinical investigation 1993-04, Vol.91 (4), p.1337-1342
Hauptverfasser:	OSHITA, M, TAKEI, Y, KAMADA, T, KAWANO, S, YOSHIHARA, H, HIJIOKA, T, FUKUI, H, GOTO, M, MASUDA, E, NISHIMURA, Y, FUSAMOTO, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Blood Pressure - drug effects Endothelins - immunology Endothelins - physiology Ethanol - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Immune Sera - pharmacology Liver - blood supply Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Nitric Oxide - metabolism omega-N-Methylarginine Other diseases. Semiology Rats Rats, Sprague-Dawley Vasoconstriction - drug effects
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