Increased radiosensitivity of granulocyte macrophage colony-forming units and skin fibroblasts in human autosomal recessive severe combined immunodeficiency

We studied the radiosensitivity of granulocyte macrophage colony-forming units (GM-CFU) in patients with a severe combined immunodeficiency (SCID). Three patients lacking both mature T and B cells showed a twofold higher GM-CFU radiosensitivity calculated as the DO value (dose required to reduce sur...

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Veröffentlicht in:	The Journal of clinical investigation 1993-03, Vol.91 (3), p.1214-1218
Hauptverfasser:	CAVAZZANA-CALVO, M, LE DEIST, F, DE SAINT BASILE, G, PAPADOPOULO, D, DE VILLARTAY, J. P, FISCHER, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bone Marrow - pathology Cell Survival - radiation effects Cells, Cultured Colony-Forming Units Assay DNA - genetics DNA - isolation & purification Dose-Response Relationship, Radiation Fibroblasts - pathology Fibroblasts - radiation effects Genes, Recessive Granulocytes - pathology Granulocytes - radiation effects Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - pathology Hematopoietic Stem Cells - radiation effects Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunologic Deficiency Syndromes - genetics Immunologic Deficiency Syndromes - immunology Immunologic Deficiency Syndromes - pathology Immunopathology Infant Macrophages - pathology Macrophages - radiation effects Male Medical sciences Reference Values Restriction Mapping Skin - pathology Skin - radiation effects T-Lymphocytes - immunology
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