Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases

Activation of androgen receptor (AR) may have a role in the development of castration-resistant prostate cancer. Two intracellular tyrosine kinases, Ack1 (activated cdc42-associated kinase) and Src, phosphorylate and enhance AR activity and promote prostate xenograft tumor growth in castrated animal...

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Veröffentlicht in:	Oncogene 2010-06, Vol.29 (22), p.3208-3216
Hauptverfasser:	Liu, Y, Karaca, M, Zhang, Z, Gioeli, D, Earp, H S, Whang, Y E
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/436/2387 692/699/67/589/466 Androgen Receptor Antagonists Androgen receptors Androgens Animals Antitumor activity Apoptosis Biological and medical sciences Bombesin Castration Cdc42 protein Cell Biology Cell Growth Processes - drug effects Cell Line, Tumor Cell physiology Cell proliferation Cell receptors Cell structures and functions Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular biology Cercopithecus aethiops COS Cells Dasatinib Dosage and administration Drug therapy Epidermal growth factor Fundamental and applied biological sciences. Psychology Genetics Heregulin Hormone receptors Human Genetics Humans Immunoblotting Interleukin 6 Internal Medicine Kinases Ligands Male Medical sciences Medicine Medicine & Public Health Mice Miscellaneous Molecular and cellular biology Nephrology. Urinary tract diseases Oncology original-article Phosphorylation Phosphorylation - drug effects Physiological aspects Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protein Kinase Inhibitors - pharmacology Protein kinases Protein-tyrosine kinase receptors Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Pyrimidines - pharmacology Receptors, Androgen - genetics Receptors, Androgen - metabolism Signal Transduction siRNA src-Family Kinases - antagonists & inhibitors src-Family Kinases - genetics src-Family Kinases - metabolism Thiazoles - pharmacology Transfection Tumors Tumors of the urinary system Urinary tract. Prostate gland Xenograft Model Antitumor Assays Xenografts
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