Design, synthesis and preliminary in vitro and in vivo evaluation of 4-[18F]fluoro-N-(2-diethylaminoethyl)benzamide ([18F]-DAFBA): A novel potential PET probe to image melanoma tumors

In order to develop a PET radiopharmaceutical to image malignant melanoma, we synthesized N -(2-diethylaminoethyl)-4-[ 18 F]fluorobenzamide ([ 18 F]-DAFBA). In vitro studies show a high uptake of [ 18 F]-DAFBA by the B16F1 melanoma cells. No significant binding was seen for DAFBA to the sigma-1 and...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioconjugate chemistry 2009-03, Vol.20 (3), p.583-590
Hauptverfasser:	Garg, Sudha, Kothari, Kanchan, Thopate, Shankar R., Doke, Aniruddha K., Garg, Pradeep K.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!