Defining the borders of splenic marginal zone lymphoma: a multiparameter study
Summary Classic splenic marginal zone lymphomas are CD5−, CD10−, CD23−, CD43−, and usually IgD+ with biphasic white pulp nodules. However, the 2008 World Health Organization classification accepts splenic marginal zone lymphomas with monophasic marginal zone-like white pulp nodules and recognizes a...
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| Veröffentlicht in: | Human pathology 2010-04, Vol.41 (4), p.540-551 |
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| creator | Dufresne, Scott D., MD Felgar, Raymond E., MD, PhD Sargent, Rachel L., MD Surti, Urvashi, PhD Gollin, Susanne M., PhD McPhail, Ellen D., MD Cook, James R., MD, PhD Swerdlow, Steven H., MD |
| description | Summary Classic splenic marginal zone lymphomas are CD5−, CD10−, CD23−, CD43−, and usually IgD+ with biphasic white pulp nodules. However, the 2008 World Health Organization classification accepts splenic marginal zone lymphomas with monophasic marginal zone-like white pulp nodules and recognizes a group of unclassifiable splenic small B-cell lymphomas. To explore the relationship of classic splenic marginal zone lymphomas to these other less well-defined splenic lymphomas, a multiparameter study of 47 splenic marginal zone lymphomas and unclassifiable splenic small B-cell lymphomas was performed. Seventeen of 31 splenic marginal zone lymphomas were biphasic, and 14 were monophasic (90%-100% marginal zone-like white pulp nodules). Sixteen cases were unclassifiable splenic small B-cell lymphomas, most lacking a marginal zone-type component. There were many clinical similarities between the 3 groups, including similar survivals. Monophasic and unclassifiable cases were less likely to have a typical splenic marginal zone lymphoma phenotype (28.6%, 23.1%) compared with biphasic cases (86.7%), usually because of IgD negativity ( P < .003). Thirty-four of 42 (81%) cases had cytogenetic abnormalities by fluorescence in situ hybridization; and 17 of 20 (85%), by classical cytogenetics. The most frequent fluorescence in situ hybridization abnormalities among the splenic marginal zone lymphomas were del(7)(q31) (26%), +12 (25%), and +3q27 (27%); and among the unclassifiable cases, +12 (50%) and +3q27 (36%). Five of 6 unclassifiable cases with exclusively small non-marginal zone-like lymphocytes involving both white and red pulp had +12 compared with 9 of 34 other cases ( P < .02). CDK6 (2 cases) and BCL3 (1 case) rearrangements were only seen in the unclassifiable group. These results support including both biphasic and monophasic cases as splenic marginal zone lymphomas, but suggest that the lack of a non-marginal zone-like population in the monophasic group is associated with some biologic differences. They also demonstrate a relatively large proportion of unclassifiable cases, including a group with frequent +12. |
| doi_str_mv | 10.1016/j.humpath.2009.09.007 |
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However, the 2008 World Health Organization classification accepts splenic marginal zone lymphomas with monophasic marginal zone-like white pulp nodules and recognizes a group of unclassifiable splenic small B-cell lymphomas. To explore the relationship of classic splenic marginal zone lymphomas to these other less well-defined splenic lymphomas, a multiparameter study of 47 splenic marginal zone lymphomas and unclassifiable splenic small B-cell lymphomas was performed. Seventeen of 31 splenic marginal zone lymphomas were biphasic, and 14 were monophasic (90%-100% marginal zone-like white pulp nodules). Sixteen cases were unclassifiable splenic small B-cell lymphomas, most lacking a marginal zone-type component. There were many clinical similarities between the 3 groups, including similar survivals. Monophasic and unclassifiable cases were less likely to have a typical splenic marginal zone lymphoma phenotype (28.6%, 23.1%) compared with biphasic cases (86.7%), usually because of IgD negativity ( P < .003). Thirty-four of 42 (81%) cases had cytogenetic abnormalities by fluorescence in situ hybridization; and 17 of 20 (85%), by classical cytogenetics. The most frequent fluorescence in situ hybridization abnormalities among the splenic marginal zone lymphomas were del(7)(q31) (26%), +12 (25%), and +3q27 (27%); and among the unclassifiable cases, +12 (50%) and +3q27 (36%). Five of 6 unclassifiable cases with exclusively small non-marginal zone-like lymphocytes involving both white and red pulp had +12 compared with 9 of 34 other cases ( P < .02). CDK6 (2 cases) and BCL3 (1 case) rearrangements were only seen in the unclassifiable group. These results support including both biphasic and monophasic cases as splenic marginal zone lymphomas, but suggest that the lack of a non-marginal zone-like population in the monophasic group is associated with some biologic differences. They also demonstrate a relatively large proportion of unclassifiable cases, including a group with frequent +12.</description><identifier>ISSN: 0046-8177</identifier><identifier>ISSN: 1532-8392</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2009.09.007</identifier><identifier>PMID: 20004934</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; B-Cell lymphoma ; Binding sites ; Biological and medical sciences ; Female ; Fluorescence in situ hybridization ; Hematologic and hematopoietic diseases ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Investigative techniques, diagnostic techniques (general aspects) ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocytes ; Lymphoma ; Lymphoma, B-Cell, Marginal Zone - classification ; Lymphoma, B-Cell, Marginal Zone - pathology ; Male ; Marginal zone lymphoma ; Medical sciences ; Middle Aged ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Spleen ; Splenic marginal zone lymphoma ; Splenic Neoplasms - classification ; Splenic Neoplasms - pathology ; Tumors</subject><ispartof>Human pathology, 2010-04, Vol.41 (4), p.540-551</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c677t-121e4b909946a378742aa57735b5450e972b92cb1c6af6937e8ee6136976d2ff3</citedby><cites>FETCH-LOGICAL-c677t-121e4b909946a378742aa57735b5450e972b92cb1c6af6937e8ee6136976d2ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humpath.2009.09.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22575794$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20004934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dufresne, Scott D., MD</creatorcontrib><creatorcontrib>Felgar, Raymond E., MD, PhD</creatorcontrib><creatorcontrib>Sargent, Rachel L., MD</creatorcontrib><creatorcontrib>Surti, Urvashi, PhD</creatorcontrib><creatorcontrib>Gollin, Susanne M., PhD</creatorcontrib><creatorcontrib>McPhail, Ellen D., MD</creatorcontrib><creatorcontrib>Cook, James R., MD, PhD</creatorcontrib><creatorcontrib>Swerdlow, Steven H., MD</creatorcontrib><title>Defining the borders of splenic marginal zone lymphoma: a multiparameter study</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary Classic splenic marginal zone lymphomas are CD5−, CD10−, CD23−, CD43−, and usually IgD+ with biphasic white pulp nodules. However, the 2008 World Health Organization classification accepts splenic marginal zone lymphomas with monophasic marginal zone-like white pulp nodules and recognizes a group of unclassifiable splenic small B-cell lymphomas. To explore the relationship of classic splenic marginal zone lymphomas to these other less well-defined splenic lymphomas, a multiparameter study of 47 splenic marginal zone lymphomas and unclassifiable splenic small B-cell lymphomas was performed. Seventeen of 31 splenic marginal zone lymphomas were biphasic, and 14 were monophasic (90%-100% marginal zone-like white pulp nodules). Sixteen cases were unclassifiable splenic small B-cell lymphomas, most lacking a marginal zone-type component. There were many clinical similarities between the 3 groups, including similar survivals. Monophasic and unclassifiable cases were less likely to have a typical splenic marginal zone lymphoma phenotype (28.6%, 23.1%) compared with biphasic cases (86.7%), usually because of IgD negativity ( P < .003). Thirty-four of 42 (81%) cases had cytogenetic abnormalities by fluorescence in situ hybridization; and 17 of 20 (85%), by classical cytogenetics. The most frequent fluorescence in situ hybridization abnormalities among the splenic marginal zone lymphomas were del(7)(q31) (26%), +12 (25%), and +3q27 (27%); and among the unclassifiable cases, +12 (50%) and +3q27 (36%). Five of 6 unclassifiable cases with exclusively small non-marginal zone-like lymphocytes involving both white and red pulp had +12 compared with 9 of 34 other cases ( P < .02). CDK6 (2 cases) and BCL3 (1 case) rearrangements were only seen in the unclassifiable group. These results support including both biphasic and monophasic cases as splenic marginal zone lymphomas, but suggest that the lack of a non-marginal zone-like population in the monophasic group is associated with some biologic differences. They also demonstrate a relatively large proportion of unclassifiable cases, including a group with frequent +12.</description><subject>Aged</subject><subject>B-Cell lymphoma</subject><subject>Binding sites</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fluorescence in situ hybridization</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphocytes</subject><subject>Lymphoma</subject><subject>Lymphoma, B-Cell, Marginal Zone - classification</subject><subject>Lymphoma, B-Cell, Marginal Zone - pathology</subject><subject>Male</subject><subject>Marginal zone lymphoma</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Spleen</subject><subject>Splenic marginal zone lymphoma</subject><subject>Splenic Neoplasms - classification</subject><subject>Splenic Neoplasms - pathology</subject><subject>Tumors</subject><issn>0046-8177</issn><issn>1532-8392</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktv1DAUhSMEotPCTwBZQqirDH47ZlGEylOqYAGsLce5mfGQxMFOKg2_HkcztNBNJUte-LvH595zi-IZwWuCiXy1W2_nfrTTdk0x1uvlYPWgWBHBaFkxTR8WK4y5LCui1ElxmtIOY0IEF4-Lk1yCuWZ8VXx5B60f_LBB0xZQHWIDMaHQojR2MHiHehs3frAd-h0GQN2-H7eht6-RRf3cTX600fYwQURpmpv9k-JRa7sET4_3WfHjw_vvl5_Kq68fP1--vSqdVGoqCSXAa4215tIyVSlOrRVKMVFngxi0orWmriZO2lZqpqACkIRJrWRD25adFRcH3XGue2gcDFO0nRmjz373Jlhv_n8Z_NZswrWhldKVklng_CgQw68Z0mR6nxx0nR0gzMkoLjEWpCL3k4wRXmFBM_niDrkLc8yzS4ZgxnWeP-OZEgfKxZBShPbGNcFmidbszDFas0RrloNVrnv-b8s3VX-zzMDLI2CTs10b7eB8uuWoUELphXtz4CAHdO0hmuQ8DA4aH8FNpgn-XisXdxRcl5cof_oT9pBuuzaJGmy-LXu4rCHOI2CCU_YHIPzZDw</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Dufresne, Scott D., MD</creator><creator>Felgar, Raymond E., MD, PhD</creator><creator>Sargent, Rachel L., MD</creator><creator>Surti, Urvashi, PhD</creator><creator>Gollin, Susanne M., PhD</creator><creator>McPhail, Ellen D., MD</creator><creator>Cook, James R., MD, PhD</creator><creator>Swerdlow, Steven H., MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20100401</creationdate><title>Defining the borders of splenic marginal zone lymphoma: a multiparameter study</title><author>Dufresne, Scott D., MD ; Felgar, Raymond E., MD, PhD ; Sargent, Rachel L., MD ; Surti, Urvashi, PhD ; Gollin, Susanne M., PhD ; McPhail, Ellen D., MD ; Cook, James R., MD, PhD ; Swerdlow, Steven H., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c677t-121e4b909946a378742aa57735b5450e972b92cb1c6af6937e8ee6136976d2ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>B-Cell lymphoma</topic><topic>Binding sites</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fluorescence in situ hybridization</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphocytes</topic><topic>Lymphoma</topic><topic>Lymphoma, B-Cell, Marginal Zone - classification</topic><topic>Lymphoma, B-Cell, Marginal Zone - pathology</topic><topic>Male</topic><topic>Marginal zone lymphoma</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Spleen</topic><topic>Splenic marginal zone lymphoma</topic><topic>Splenic Neoplasms - classification</topic><topic>Splenic Neoplasms - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dufresne, Scott D., MD</creatorcontrib><creatorcontrib>Felgar, Raymond E., MD, PhD</creatorcontrib><creatorcontrib>Sargent, Rachel L., MD</creatorcontrib><creatorcontrib>Surti, Urvashi, PhD</creatorcontrib><creatorcontrib>Gollin, Susanne M., PhD</creatorcontrib><creatorcontrib>McPhail, Ellen D., MD</creatorcontrib><creatorcontrib>Cook, James R., MD, PhD</creatorcontrib><creatorcontrib>Swerdlow, Steven H., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dufresne, Scott D., MD</au><au>Felgar, Raymond E., MD, PhD</au><au>Sargent, Rachel L., MD</au><au>Surti, Urvashi, PhD</au><au>Gollin, Susanne M., PhD</au><au>McPhail, Ellen D., MD</au><au>Cook, James R., MD, PhD</au><au>Swerdlow, Steven H., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Defining the borders of splenic marginal zone lymphoma: a multiparameter study</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>41</volume><issue>4</issue><spage>540</spage><epage>551</epage><pages>540-551</pages><issn>0046-8177</issn><issn>1532-8392</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary Classic splenic marginal zone lymphomas are CD5−, CD10−, CD23−, CD43−, and usually IgD+ with biphasic white pulp nodules. However, the 2008 World Health Organization classification accepts splenic marginal zone lymphomas with monophasic marginal zone-like white pulp nodules and recognizes a group of unclassifiable splenic small B-cell lymphomas. To explore the relationship of classic splenic marginal zone lymphomas to these other less well-defined splenic lymphomas, a multiparameter study of 47 splenic marginal zone lymphomas and unclassifiable splenic small B-cell lymphomas was performed. Seventeen of 31 splenic marginal zone lymphomas were biphasic, and 14 were monophasic (90%-100% marginal zone-like white pulp nodules). Sixteen cases were unclassifiable splenic small B-cell lymphomas, most lacking a marginal zone-type component. There were many clinical similarities between the 3 groups, including similar survivals. Monophasic and unclassifiable cases were less likely to have a typical splenic marginal zone lymphoma phenotype (28.6%, 23.1%) compared with biphasic cases (86.7%), usually because of IgD negativity ( P < .003). Thirty-four of 42 (81%) cases had cytogenetic abnormalities by fluorescence in situ hybridization; and 17 of 20 (85%), by classical cytogenetics. The most frequent fluorescence in situ hybridization abnormalities among the splenic marginal zone lymphomas were del(7)(q31) (26%), +12 (25%), and +3q27 (27%); and among the unclassifiable cases, +12 (50%) and +3q27 (36%). Five of 6 unclassifiable cases with exclusively small non-marginal zone-like lymphocytes involving both white and red pulp had +12 compared with 9 of 34 other cases ( P < .02). CDK6 (2 cases) and BCL3 (1 case) rearrangements were only seen in the unclassifiable group. These results support including both biphasic and monophasic cases as splenic marginal zone lymphomas, but suggest that the lack of a non-marginal zone-like population in the monophasic group is associated with some biologic differences. They also demonstrate a relatively large proportion of unclassifiable cases, including a group with frequent +12.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20004934</pmid><doi>10.1016/j.humpath.2009.09.007</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged B-Cell lymphoma Binding sites Biological and medical sciences Female Fluorescence in situ hybridization Hematologic and hematopoietic diseases Humans Immunohistochemistry In Situ Hybridization, Fluorescence Investigative techniques, diagnostic techniques (general aspects) Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes Lymphoma Lymphoma, B-Cell, Marginal Zone - classification Lymphoma, B-Cell, Marginal Zone - pathology Male Marginal zone lymphoma Medical sciences Middle Aged Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Spleen Splenic marginal zone lymphoma Splenic Neoplasms - classification Splenic Neoplasms - pathology Tumors |
| title | Defining the borders of splenic marginal zone lymphoma: a multiparameter study |
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