Recombinant Newcastle Disease Virus as a Vaccine Vector for Cancer Therapy

Naturally occurring strains of Newcastle disease virus (NDV) are currently being investigated in multiple clinical trials for oncolytic cancer therapy in the United States and abroad. We have previously reported, for the first time, the development of recombinant NDVs designed for enhanced cancer th...

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Veröffentlicht in:	Molecular therapy 2008-11, Vol.16 (11), p.1883-1890
Hauptverfasser:	Vigil, Adam, Martinez, Osvaldo, Chua, Mark A, García-Sastre, Adolfo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - genetics beta-Galactosidase - biosynthesis Cancer therapies Cancer Vaccines - immunology Cancer Vaccines - therapeutic use CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Clinical trials Colon Cytokines Disease Endoplasmic reticulum Epitopes, T-Lymphocyte Female Gene therapy Genetic Vectors Histocompatibility Antigens Class II - biosynthesis Immune system Immunotherapy Interleukin-2 - genetics Lymph Nodes - pathology Lymphocytes Medicine Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Neoplasms, Experimental - immunology Neoplasms, Experimental - pathology Neoplasms, Experimental - therapy Newcastle disease virus - genetics Newcastle disease virus - metabolism Oncolytic Viruses - genetics Oncolytic Viruses - metabolism Transplantation, Heterologous Tumors Vaccines Viruses
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