Biochemical Conservation and Evolution of Germacrene A Oxidase in Asteraceae

Sesquiterpene lactones are characteristic natural products in Asteraceae, which constitutes ∼8% of all plant species. Despite their physiological and pharmaceutical importance, the biochemistry and evolution of sesquiterpene lactones remain unexplored. Here we show that germacrene A oxidase (GAO), e...

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Veröffentlicht in:	The Journal of biological chemistry 2010-05, Vol.285 (22), p.16588-16598
Hauptverfasser:	Nguyen, Don Trinh, Göpfert, Jens Christian, Ikezawa, Nobuhiro, MacNevin, Gillian, Kathiresan, Meena, Conrad, Jürgen, Spring, Otmar, Ro, Dae-Kyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Asteraceae - enzymology Catalysis Chromatography, Thin Layer - methods Cytochrome P-450 Enzyme System - chemistry Cytochrome P450 Enzyme Catalysis Evolution Evolution, Molecular Gene Expression Regulation Genetic Variation Magnetic Resonance Spectroscopy Mass Spectrometry (MS) Mass Spectrometry - methods Metabolism Microsomes - metabolism Molecular Sequence Data Oxidoreductases - chemistry Oxidoreductases - genetics Plant Plant Biology Plant Proteins - metabolism Recombinant Proteins - chemistry Sesquiterpenes, Germacrane - chemistry Sesquiterpenes, Germacrane - genetics
Online-Zugang:	Volltext
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