Keratocyte phenotype mediates proteoglycan structure: a role for fibroblasts in corneal fibrosis

In pathological corneas, accumulation of fibrotic extracellular matrix is characterized by proteoglycans with altered glycosaminoglycans that contribute to the reduced transparency of scarred tissue. During wound healing, keratocytes in the corneal stroma transdifferentiate into fibroblasts and myof...

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Veröffentlicht in:	The Journal of biological chemistry 2003-11, Vol.278 (46), p.45629-45637
Hauptverfasser:	Funderburgh, James L, Mann, Mary M, Funderburgh, Martha L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon - chemistry Cattle Cell Differentiation Collagen - chemistry Corneal Diseases - metabolism Dermatan Sulfate - chemistry Electrophoresis, Polyacrylamide Gel Fibroblasts - metabolism Fibrosis - metabolism Glycosaminoglycans - chemistry Glycoside Hydrolases - metabolism Hyaluronic Acid - chemistry Immunoblotting Keratan Sulfate - chemistry Keratinocytes - metabolism Molecular Sequence Data Phenotype Proteoglycans - chemistry Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism
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