Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys
Systemic levels of proinflammatory cytokines such as interleukin-6 (IL-6) increase in old age and may contribute to neural atrophy in humans. We investigated IL-6 associations with age in T1-weighted segments and microstructural diffusion indices using MRI in aged rhesus monkeys (Macaca mulatta). Fu...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2010-07, Vol.51 (3), p.987-994 |
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| creator | Willette, A.A. Bendlin, B.B. McLaren, D.G. Canu, E. Kastman, E.K. Kosmatka, K.J. Xu, G. Field, A.S. Alexander, A.L. Colman, R.J. Weindruch, R.H. Coe, C.L. Johnson, S.C. |
| description | Systemic levels of proinflammatory cytokines such as interleukin-6 (IL-6) increase in old age and may contribute to neural atrophy in humans. We investigated IL-6 associations with age in T1-weighted segments and microstructural diffusion indices using MRI in aged rhesus monkeys (Macaca mulatta). Further, we determined if long-term 30% calorie restriction (CR) reduced IL-6 and attenuated its association with lower tissue volume and density. Voxel-based morphometry (VBM) and diffusion-weighted voxelwise analyses were conducted. IL-6 was associated with less global gray and white matter (GM and WM), as well as smaller parietal and temporal GM volumes. Lower fractional anisotropy (FA) was associated with higher IL-6 levels along the corpus callosum and various cortical and subcortical tracts. Higher IL-6 concentrations across subjects were also associated with increased mean diffusivity (MD) throughout many brain regions, particularly in corpus callosum, cingulum, and parietal, frontal, and prefrontal areas. CR monkeys had significantly lower IL-6 and less associated atrophy. An IL-6×CR interaction across modalities also indicated that CR mitigated IL-6 related changes in several brain regions compared to controls. Peripheral IL-6 levels were correlated with atrophy in regions sensitive to aging, and this relationship was decreased by CR. |
| doi_str_mv | 10.1016/j.neuroimage.2010.03.015 |
| format | Article |
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We investigated IL-6 associations with age in T1-weighted segments and microstructural diffusion indices using MRI in aged rhesus monkeys (Macaca mulatta). Further, we determined if long-term 30% calorie restriction (CR) reduced IL-6 and attenuated its association with lower tissue volume and density. Voxel-based morphometry (VBM) and diffusion-weighted voxelwise analyses were conducted. IL-6 was associated with less global gray and white matter (GM and WM), as well as smaller parietal and temporal GM volumes. Lower fractional anisotropy (FA) was associated with higher IL-6 levels along the corpus callosum and various cortical and subcortical tracts. Higher IL-6 concentrations across subjects were also associated with increased mean diffusivity (MD) throughout many brain regions, particularly in corpus callosum, cingulum, and parietal, frontal, and prefrontal areas. CR monkeys had significantly lower IL-6 and less associated atrophy. An IL-6×CR interaction across modalities also indicated that CR mitigated IL-6 related changes in several brain regions compared to controls. Peripheral IL-6 levels were correlated with atrophy in regions sensitive to aging, and this relationship was decreased by CR.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2010.03.015</identifier><identifier>PMID: 20298794</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age ; Aging ; Aging - metabolism ; Aging - pathology ; Animals ; Atrophy ; Biomarkers ; Brain ; Brain - anatomy & histology ; Brain - metabolism ; Caloric Restriction - methods ; Calorie restriction ; Female ; Interleukin-6 ; Interleukin-6 - blood ; Interleukins - blood ; Macaca mulatta ; Magnetic Resonance Imaging ; Male ; Microstructure ; Monkey ; Organ Size ; Oxidative stress ; Proteins ; Rodents ; Studies ; Voxel-based morphometry</subject><ispartof>NeuroImage (Orlando, Fla.), 2010-07, Vol.51 (3), p.987-994</ispartof><rights>2010</rights><rights>Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited Jul 1, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-e66dd1f72e87bf5de51e280b34455bd0564c33aa47d751f340b45a4319ebae8b3</citedby><cites>FETCH-LOGICAL-c506t-e66dd1f72e87bf5de51e280b34455bd0564c33aa47d751f340b45a4319ebae8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1053811910002855$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20298794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Willette, A.A.</creatorcontrib><creatorcontrib>Bendlin, B.B.</creatorcontrib><creatorcontrib>McLaren, D.G.</creatorcontrib><creatorcontrib>Canu, E.</creatorcontrib><creatorcontrib>Kastman, E.K.</creatorcontrib><creatorcontrib>Kosmatka, K.J.</creatorcontrib><creatorcontrib>Xu, G.</creatorcontrib><creatorcontrib>Field, A.S.</creatorcontrib><creatorcontrib>Alexander, A.L.</creatorcontrib><creatorcontrib>Colman, R.J.</creatorcontrib><creatorcontrib>Weindruch, R.H.</creatorcontrib><creatorcontrib>Coe, C.L.</creatorcontrib><creatorcontrib>Johnson, S.C.</creatorcontrib><title>Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>Systemic levels of proinflammatory cytokines such as interleukin-6 (IL-6) increase in old age and may contribute to neural atrophy in humans. We investigated IL-6 associations with age in T1-weighted segments and microstructural diffusion indices using MRI in aged rhesus monkeys (Macaca mulatta). Further, we determined if long-term 30% calorie restriction (CR) reduced IL-6 and attenuated its association with lower tissue volume and density. Voxel-based morphometry (VBM) and diffusion-weighted voxelwise analyses were conducted. IL-6 was associated with less global gray and white matter (GM and WM), as well as smaller parietal and temporal GM volumes. Lower fractional anisotropy (FA) was associated with higher IL-6 levels along the corpus callosum and various cortical and subcortical tracts. Higher IL-6 concentrations across subjects were also associated with increased mean diffusivity (MD) throughout many brain regions, particularly in corpus callosum, cingulum, and parietal, frontal, and prefrontal areas. CR monkeys had significantly lower IL-6 and less associated atrophy. An IL-6×CR interaction across modalities also indicated that CR mitigated IL-6 related changes in several brain regions compared to controls. Peripheral IL-6 levels were correlated with atrophy in regions sensitive to aging, and this relationship was decreased by CR.</description><subject>Age</subject><subject>Aging</subject><subject>Aging - metabolism</subject><subject>Aging - pathology</subject><subject>Animals</subject><subject>Atrophy</subject><subject>Biomarkers</subject><subject>Brain</subject><subject>Brain - anatomy & histology</subject><subject>Brain - metabolism</subject><subject>Caloric Restriction - methods</subject><subject>Calorie restriction</subject><subject>Female</subject><subject>Interleukin-6</subject><subject>Interleukin-6 - blood</subject><subject>Interleukins - blood</subject><subject>Macaca mulatta</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Microstructure</subject><subject>Monkey</subject><subject>Organ Size</subject><subject>Oxidative stress</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Studies</subject><subject>Voxel-based morphometry</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc2OFCEUhYnROGPrKxgSF66qhQKqqI3JOPEvmcSNrgkFt7vpoWCEoif9Jj6u1PQ4_mxMSIrc-u65nHsQwpSsKaHdm_06QEnRTXoL65bUMmFrQsUjdE7JIJpB9O3j5S5YIykdztCznPeEkIFy-RSdtaQdZD_wc_TjYgtNAq9nsNjsdNhCxi7gRV97fIi-TIB1sHhyJsU8p2Lmkmop52jcXdutm3e1Z4bkoVy70HRYL8QE3sV0h4xHrLHRPia3jKsyzix162BexkVvcdpBLhlPMVzDMT9HTzbaZ3hx_12hbx_ef7381Fx9-fj58uKqMYJ0cwNdZy3d9C3IftwIC4JCK8nIOBditER03DCmNe9tL-iGcTJyoTmjA4wa5MhW6O1J96aME1gDYa7G1U2qy01HFbVTf_8Jbqe28aBa2fesnhV6fS-Q4vdSranJZQPe6wCxZNUzRinloqvkq3_IfSwpVHeKVjOSSUZJpeSJWtadE2we3kKJWtJXe_U7fbWkrwhTNf3a-vJPLw-Nv-KuwLsTAHWjBwdJZeMgGLAugZmVje7_U34CDQ_KjA</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Willette, A.A.</creator><creator>Bendlin, B.B.</creator><creator>McLaren, D.G.</creator><creator>Canu, E.</creator><creator>Kastman, E.K.</creator><creator>Kosmatka, K.J.</creator><creator>Xu, G.</creator><creator>Field, A.S.</creator><creator>Alexander, A.L.</creator><creator>Colman, R.J.</creator><creator>Weindruch, R.H.</creator><creator>Coe, C.L.</creator><creator>Johnson, S.C.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100701</creationdate><title>Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys</title><author>Willette, A.A. ; Bendlin, B.B. ; McLaren, D.G. ; Canu, E. ; Kastman, E.K. ; Kosmatka, K.J. ; Xu, G. ; Field, A.S. ; Alexander, A.L. ; Colman, R.J. ; Weindruch, R.H. ; Coe, C.L. ; Johnson, S.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-e66dd1f72e87bf5de51e280b34455bd0564c33aa47d751f340b45a4319ebae8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Age</topic><topic>Aging</topic><topic>Aging - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Willette, A.A.</au><au>Bendlin, B.B.</au><au>McLaren, D.G.</au><au>Canu, E.</au><au>Kastman, E.K.</au><au>Kosmatka, K.J.</au><au>Xu, G.</au><au>Field, A.S.</au><au>Alexander, A.L.</au><au>Colman, R.J.</au><au>Weindruch, R.H.</au><au>Coe, C.L.</au><au>Johnson, S.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>51</volume><issue>3</issue><spage>987</spage><epage>994</epage><pages>987-994</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>Systemic levels of proinflammatory cytokines such as interleukin-6 (IL-6) increase in old age and may contribute to neural atrophy in humans. We investigated IL-6 associations with age in T1-weighted segments and microstructural diffusion indices using MRI in aged rhesus monkeys (Macaca mulatta). Further, we determined if long-term 30% calorie restriction (CR) reduced IL-6 and attenuated its association with lower tissue volume and density. Voxel-based morphometry (VBM) and diffusion-weighted voxelwise analyses were conducted. IL-6 was associated with less global gray and white matter (GM and WM), as well as smaller parietal and temporal GM volumes. Lower fractional anisotropy (FA) was associated with higher IL-6 levels along the corpus callosum and various cortical and subcortical tracts. Higher IL-6 concentrations across subjects were also associated with increased mean diffusivity (MD) throughout many brain regions, particularly in corpus callosum, cingulum, and parietal, frontal, and prefrontal areas. CR monkeys had significantly lower IL-6 and less associated atrophy. An IL-6×CR interaction across modalities also indicated that CR mitigated IL-6 related changes in several brain regions compared to controls. Peripheral IL-6 levels were correlated with atrophy in regions sensitive to aging, and this relationship was decreased by CR.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20298794</pmid><doi>10.1016/j.neuroimage.2010.03.015</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | NeuroImage (Orlando, Fla.), 2010-07, Vol.51 (3), p.987-994 |
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| subjects | Age Aging Aging - metabolism Aging - pathology Animals Atrophy Biomarkers Brain Brain - anatomy & histology Brain - metabolism Caloric Restriction - methods Calorie restriction Female Interleukin-6 Interleukin-6 - blood Interleukins - blood Macaca mulatta Magnetic Resonance Imaging Male Microstructure Monkey Organ Size Oxidative stress Proteins Rodents Studies Voxel-based morphometry |
| title | Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys |
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