Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function

Sac family phosphoinositide (PI) phosphatases are an essential family of CX 5 R(T/S)‐based enzymes, involved in numerous aspects of cellular function such as PI homeostasis, cellular signalling, and membrane trafficking. Genetic deletions of several Sac family members result in lethality in animal m...

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Veröffentlicht in:	The EMBO journal 2010-05, Vol.29 (9), p.1489-1498
Hauptverfasser:	Manford, Andrew, Xia, Tian, Saxena, Ajay Kumar, Stefan, Christopher, Hu, Fenghua, Emr, Scott D, Mao, Yuxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal models Catalytic Domain Crystal structure Crystallography, X-Ray EMBO20 EMBO37 EMBO40 Enzymes Flavoproteins - chemistry Flavoproteins - genetics Genetics Humans lipid metabolism Models, Molecular Molecular biology Molecular Sequence Data Mutation Mutation, Missense phosphatase phosphoinositide Phosphoric Monoester Hydrolases - chemistry Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Protein Conformation Protein Folding Sac1 Sac3/Fig4 Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Alignment Structural Homology, Protein Yeasts
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