Kv1.3 is the exclusive voltage‐gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count

A delayed rectifier voltage‐gated K+ channel (Kv) represents the largest ionic conductance of platelets and megakaryocytes, but is undefined at the molecular level. Quantitative RT‐PCR of all known Kv α and ancillary subunits showed that only Kv1.3 (KCNA3) is substantially expressed in human platele...

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Veröffentlicht in:	The Journal of physiology 2010-05, Vol.588 (9), p.1399-1406
Hauptverfasser:	McCloskey, Conor, Jones, Sarah, Amisten, Stefan, Snowden, Roger T., Kaczmarek, Leonard K., Erlinge, David, Goodall, Alison H., Forsythe, Ian D., Mahaut‐Smith, Martyn P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood platelets Blood Platelets - drug effects Blood Platelets - physiology Blood Platelets - ultrastructure Calcium Signaling - drug effects Calcium Signaling - physiology Cell Size DNA, Complementary - biosynthesis DNA, Complementary - genetics Humans In Vitro Techniques Kv1.3 Potassium Channel - blood Megakaryocytes - drug effects Megakaryocytes - physiology Megakaryocytes - ultrastructure Membrane Potentials - drug effects Membrane Potentials - physiology Mice Mice, Inbred C57BL Molecular and Cellular Patch-Clamp Techniques Platelet Count Reverse Transcriptase Polymerase Chain Reaction Rodents Scorpion Venoms - pharmacology Second Messenger Systems - physiology
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