The identification and biochemical characterization of drug-like compounds that inhibit botulinum neurotoxin serotype A endopeptidase activity

A robust, high-throughput, two-tiered assay for screening small molecule inhibitors against botulinum neurotoxin serotype A was developed and employed to screen 16,544 compounds. Thirty-four compounds were identified as potent hits employing the first-tier assay. Subsequently, nine were confirmed as...

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Veröffentlicht in:Toxicon (Oxford) 2010-04, Vol.55 (4), p.818-826
Hauptverfasser: Cai, Shuowei, Lindo, Paul, Park, Jong-Beak, Vasa, Kruti, Singh, Bal Ram
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Sprache:eng
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