Possible Important Pair of Acidic Residues in Vesicular Acetylcholine Transporter

Invariant E309 is in contact with critical and invariant D398 in a three-dimensional homology model of vesicular acetylcholine transporter (VAChT, TC 2.A.1.2.13) [Vardy, E., et al. (2004) Protein Sci. 13, 1832−1840]. In the work reported here, E309 and D398 in human VAChT were mutated singly and tog...

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Veröffentlicht in:	Biochemistry (Easton) 2010-04, Vol.49 (14), p.3049-3059
Hauptverfasser:	Khare, Parul, Ojeda, Ana M, Chandrasekaran, Ananda, Parsons, Stanley M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Animals Biological Transport Humans Hydrogen-Ion Concentration Models, Molecular Mutation PC12 Cells Piperidines - metabolism Protein Conformation Radioligand Assay Rats Vesicular Acetylcholine Transport Proteins - genetics Vesicular Acetylcholine Transport Proteins - metabolism
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