The effect of the pro-inflammatory cytokine tumor necrosis factor-alpha on human joint capsule myofibroblasts

Previous studies have shown that the number of myoblastically differentiated fibroblasts known as myofibroblasts (MFs) is significantly increased in stiff joint capsules, indicating their crucial role in the pathogenesis of post-traumatic joint stiffness. Although the mode of MFs' function has...

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Veröffentlicht in:	Arthritis research & therapy 2010-01, Vol.12 (1), p.R4-R4, Article R4
Hauptverfasser:	Mattyasovszky, Stefan G, Hofmann, Alexander, Brochhausen, Christoph, Ritz, Ulrike, Kuhn, Sebastian, Wollstädter, Jochen, Schulze-Koops, Hendrik, Müller, Lars P, Watzer, Bernhard, Rommens, Pol M
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - biosynthesis Aged Antibodies, Monoclonal - pharmacology Antirheumatic Agents - pharmacology Blotting, Western Cell Proliferation - drug effects Cells, Cultured Collagen Type I - biosynthesis Contracture - metabolism Cyclooxygenase 2 - biosynthesis Cyclooxygenase 2 Inhibitors - pharmacology Cytokines Cytokines - metabolism Diclofenac - pharmacology Dinoprost - biosynthesis Dinoprostone - biosynthesis Elbow Joint - pathology Extracellular Matrix - metabolism Female Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fluorescent Antibody Technique Gene expression Gene Expression - drug effects Hip Joint Humans Immunohistochemistry Inflammation Mediators - metabolism Infliximab Joint Capsule - metabolism Joint Capsule - pathology Male Middle Aged Physiological aspects Prostaglandins F - biosynthesis Research article Reverse Transcriptase Polymerase Chain Reaction Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism
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