Association of A1C Levels With Vitamin D Status in U.S. Adults: Data from the National Health and Nutrition Examination Survey
Data relating vitamin D status with indices of glucose homeostasis as manifested by A1C in the U.S. adult population are few. We examined the association between serum 25 hydroxyvitamin D [25(OH)D] and A1C levels in 9,773 adults (age >or=18 years old) participating in the 2003-2006 National Healt...
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| Veröffentlicht in: | Diabetes care 2010-06, Vol.33 (6), p.1236-1238 |
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| creator | KOSITSAWAT, Jatupol FREEMAN, Vincent L GERBER, Ben S GERACI, Stephen |
| description | Data relating vitamin D status with indices of glucose homeostasis as manifested by A1C in the U.S. adult population are few.
We examined the association between serum 25 hydroxyvitamin D [25(OH)D] and A1C levels in 9,773 adults (age >or=18 years old) participating in the 2003-2006 National Health and Nutrition Examination Survey. Multivariate linear regression analyzed the association after accounting for potential confounders. RESULTS Serum 25(OH)D levels were inversely associated with A1C levels in subjects age 35-74 years (P = 0.0045) and those who did not report a history of diabetes (P = 0.0282).
These findings support a mechanistic link between serum vitamin D concentrations, glucose homeostasis, and the evolution of diabetes in a large segment of the U.S. adult population. Screening people with elevated A1C levels for vitamin D insufficiency should be considered. |
| doi_str_mv | 10.2337/dc09-2150 |
| format | Article |
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We examined the association between serum 25 hydroxyvitamin D [25(OH)D] and A1C levels in 9,773 adults (age >or=18 years old) participating in the 2003-2006 National Health and Nutrition Examination Survey. Multivariate linear regression analyzed the association after accounting for potential confounders. RESULTS Serum 25(OH)D levels were inversely associated with A1C levels in subjects age 35-74 years (P = 0.0045) and those who did not report a history of diabetes (P = 0.0282).
These findings support a mechanistic link between serum vitamin D concentrations, glucose homeostasis, and the evolution of diabetes in a large segment of the U.S. adult population. Screening people with elevated A1C levels for vitamin D insufficiency should be considered.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc09-2150</identifier><identifier>PMID: 20215453</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Adult ; Adults ; Age Factors ; Aged ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Dextrose ; Diabetes ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Glucose ; Glycated Hemoglobin A - metabolism ; Health surveys ; Humans ; Linear Models ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Miscellaneous ; Multivariate Analysis ; Original Research ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Radioimmunoassay ; Surveys ; United States ; Vitamin D - blood ; Vitamins</subject><ispartof>Diabetes care, 2010-06, Vol.33 (6), p.1236-1238</ispartof><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 American Diabetes Association</rights><rights>2010 by the American Diabetes Association. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22878966$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20215453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOSITSAWAT, Jatupol</creatorcontrib><creatorcontrib>FREEMAN, Vincent L</creatorcontrib><creatorcontrib>GERBER, Ben S</creatorcontrib><creatorcontrib>GERACI, Stephen</creatorcontrib><title>Association of A1C Levels With Vitamin D Status in U.S. Adults: Data from the National Health and Nutrition Examination Survey</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>Data relating vitamin D status with indices of glucose homeostasis as manifested by A1C in the U.S. adult population are few.
We examined the association between serum 25 hydroxyvitamin D [25(OH)D] and A1C levels in 9,773 adults (age >or=18 years old) participating in the 2003-2006 National Health and Nutrition Examination Survey. Multivariate linear regression analyzed the association after accounting for potential confounders. RESULTS Serum 25(OH)D levels were inversely associated with A1C levels in subjects age 35-74 years (P = 0.0045) and those who did not report a history of diabetes (P = 0.0282).
These findings support a mechanistic link between serum vitamin D concentrations, glucose homeostasis, and the evolution of diabetes in a large segment of the U.S. adult population. Screening people with elevated A1C levels for vitamin D insufficiency should be considered.</description><subject>Adult</subject><subject>Adults</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dextrose</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Glucose</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Health surveys</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Multivariate Analysis</subject><subject>Original Research</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Radioimmunoassay</subject><subject>Surveys</subject><subject>United States</subject><subject>Vitamin D - blood</subject><subject>Vitamins</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkV1v0zAUhi0EYt3ggj-ALCHEVYrjjyTmAinqBkOqxkUZXEYnjtMaOfYWOxW72W_HXcvHpMoXto6f8xy9NkKvcjKnjJXvO0VkRnNBnqBZLpnIhODVUzQjOZeZkJKeoNMQfhJCOK-q5-iEkkRzwWbovg7BKwPReId9j-t8gZd6q23AP0zc4O8mwmAcPserCHEKOJ2v56s5rrvJxvABn0ME3I9-wHGj8dWDCCy-1GBTO7gOX01xNA_-i187137Wahq3-u4FetaDDfrlYT9D158uvi0us-XXz18W9TJbc0JixqHtleaKdm0vSFvltOuV6EpVqbIgtC0KVgCVBDgTrShyJgutWsKpTGDHc3aGPu69N1M76E5pF0ewzc1oBhjvGg-meXzjzKZZ-21Dq1JwRpLg3UEw-ttJh9gMJihtLTjtp9CUjOWkKBlN5Js9uQarG-N6n4RqRzc1pZUkoqA7X3aEWmun03TvdG9S-RE_P8Kn1enBqKMNr_9P_Dfqn69PwNsDAEGB7UdwyoR_XEpeyfSwvwGp-7sa</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>KOSITSAWAT, Jatupol</creator><creator>FREEMAN, Vincent L</creator><creator>GERBER, Ben S</creator><creator>GERACI, Stephen</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100601</creationdate><title>Association of A1C Levels With Vitamin D Status in U.S. Adults: Data from the National Health and Nutrition Examination Survey</title><author>KOSITSAWAT, Jatupol ; FREEMAN, Vincent L ; GERBER, Ben S ; GERACI, Stephen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g400t-4abfce4c2dbf50b812dfc5d7c8c7602b6636a290a435b561396ecb04292dfd413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dextrose</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Glucose</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Health surveys</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Multivariate Analysis</topic><topic>Original Research</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Radioimmunoassay</topic><topic>Surveys</topic><topic>United States</topic><topic>Vitamin D - blood</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOSITSAWAT, Jatupol</creatorcontrib><creatorcontrib>FREEMAN, Vincent L</creatorcontrib><creatorcontrib>GERBER, Ben S</creatorcontrib><creatorcontrib>GERACI, Stephen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOSITSAWAT, Jatupol</au><au>FREEMAN, Vincent L</au><au>GERBER, Ben S</au><au>GERACI, Stephen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of A1C Levels With Vitamin D Status in U.S. Adults: Data from the National Health and Nutrition Examination Survey</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>33</volume><issue>6</issue><spage>1236</spage><epage>1238</epage><pages>1236-1238</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>Data relating vitamin D status with indices of glucose homeostasis as manifested by A1C in the U.S. adult population are few.
We examined the association between serum 25 hydroxyvitamin D [25(OH)D] and A1C levels in 9,773 adults (age >or=18 years old) participating in the 2003-2006 National Health and Nutrition Examination Survey. Multivariate linear regression analyzed the association after accounting for potential confounders. RESULTS Serum 25(OH)D levels were inversely associated with A1C levels in subjects age 35-74 years (P = 0.0045) and those who did not report a history of diabetes (P = 0.0282).
These findings support a mechanistic link between serum vitamin D concentrations, glucose homeostasis, and the evolution of diabetes in a large segment of the U.S. adult population. Screening people with elevated A1C levels for vitamin D insufficiency should be considered.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>20215453</pmid><doi>10.2337/dc09-2150</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes care, 2010-06, Vol.33 (6), p.1236-1238 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Adults Age Factors Aged Biological and medical sciences Chromatography, High Pressure Liquid Dextrose Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Glucose Glycated Hemoglobin A - metabolism Health surveys Humans Linear Models Male Medical sciences Metabolic diseases Middle Aged Miscellaneous Multivariate Analysis Original Research Public health. Hygiene Public health. Hygiene-occupational medicine Radioimmunoassay Surveys United States Vitamin D - blood Vitamins |
| title | Association of A1C Levels With Vitamin D Status in U.S. Adults: Data from the National Health and Nutrition Examination Survey |
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