Solid State 2H NMR Analysis of Furanose Ring Dynamics in DNA Containing Uracil

DNA damage has been implicated in numerous human diseases, particularly cancer, and the aging process. Single-base lesions, such as uracil, in DNA can be cytotoxic or mutagenic and are recognized by a DNA glycosylase during the process of base excision repair. Increased dynamic properties in lesion-...

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Veröffentlicht in:	The journal of physical chemistry. B 2010-03, Vol.114 (9), p.3285-3293
Hauptverfasser:	Kinde-Carson, Monica N, Ferguson, Crystal, Oyler, Nathan A, Harbison, Gerard S, Meints, Gary A
Format:	Artikel
Sprache:	eng
Schlagworte:	B: Biophysical Chemistry Base Pairing Computer Simulation DNA - chemistry DNA Glycosylases - metabolism DNA Repair Magnetic Resonance Spectroscopy Uracil - chemistry
Online-Zugang:	Volltext
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