Acupuncture for Chemotherapy-Induced Neutropenia in Patients with Gynecologic Malignancies: A Pilot Randomized, Sham-Controlled Clinical Trial
Objectives: The objective of this study was to investigate the effect of acupuncture administered during myelosuppressive chemotherapy on white blood cell (WBC) count and absolute neutrophil count (ANC) in patients with ovarian cancer. Design: This study is a pilot, randomized, sham-controlled clini...
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| Veröffentlicht in: | The journal of alternative and complementary medicine (New York, N.Y.) N.Y.), 2009-07, Vol.15 (7), p.745-753 |
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| creator | Lu, Weidong Matulonis, Ursula A. Doherty-Gilman, Anne Lee, Hang Dean-Clower, Elizabeth Rosulek, Andrew Gibson, Carolyn Goodman, Annekathryn Davis, Roger B. Buring, Julie E. Wayne, Peter M. Rosenthal, David S. Penson, Richard T. |
| description | Objectives:
The objective of this study was to investigate the effect of acupuncture administered during myelosuppressive chemotherapy on white blood cell (WBC) count and absolute neutrophil count (ANC) in patients with ovarian cancer.
Design:
This study is a pilot, randomized, sham-controlled clinical trial. Patients received active acupuncture versus sham acupuncture while undergoing chemotherapy. A standardized acupuncture protocol was employed with manual and electrostimulation. The frequency of treatment was 2–3 times per week for a total of 10 sessions, starting 1 week before the second cycle of chemotherapy.
Setting:
The setting was two outpatient academic centers for patients with cancer.
Subjects:
Twenty-one (21) newly diagnosed and recurrent ovarian cancer patients were the subjects.
Outcome measures:
WBC count, ANC, and plasma granulocyte colony-stimulating factor (G-CSF ) were assessed weekly.
Results:
The median leukocyte value in the acupuncture arm at the first day of the third cycle of chemotherapy was significantly higher than in the control arm after adjusting for baseline value (8600 cells/μL, range: 4800–12,000 versus 4400 cell/μL, range: 2300–10,000) (
p
= 0.046). The incidence of grade 2–4 leukopenia was less in the acupuncture arm than in the sham arm (30% versus 90%;
p
= 0.02). However, the median leukocyte nadir, neutrophil nadir, and recovering ANC were all higher but not statistically significantly different (
p
= 0.116–0.16), after adjusting for baseline differences. There were no statistically significant differences in plasma G-CSF between the two groups.
Conclusions:
We observed clinically relevant trends of higher WBC values during one cycle of chemotherapy in patients with ovarian cancer, which suggests a potential myeloprotective effect of acupuncture. A larger trial is warranted to more definitively determine the efficacy of acupuncture on clinically important outcomes of chemotherapy-induced neutropenia. |
| doi_str_mv | 10.1089/acm.2008.0589 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2875080</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19552597</sourcerecordid><originalsourceid>FETCH-LOGICAL-c429t-7c177bc1746de68bbc8f8d778fff7540ff9fd9329064c263641e8dab329233d83</originalsourceid><addsrcrecordid>eNqFkctu3CAUhlHVqkmTLruteIB6ii8Y6KLSyErSSLkpTdcIcxlTYbAwTjR5iD5zGU2UpKtuOOicn-8IfQB8KtGqRJR9FXJcVQjRFcKUvQGHJcakIATRt_mOCC4wrvEB-DDPvxFCTcOq9-CgZBhXmJFD8Gctl2nxMi1RQxMi7AY9hjToKKZtce7VIrWCV3pJMUzaWwGthzciWe3TDB9sGuDZ1msZXNhYCS-FsxsvvLR6_gbX8Ma6kOCt8CqM9lGrL_DnIMaiCz7znMvozllvpXDwLlrhjsE7I9ysPz7VI_Dr9OSu-1FcXJ-dd-uLQjYVSwWRJSF9PppW6Zb2vaSGKkKoMYbgBhnDjGJ1xVDbyKqt26bUVIk-d6q6VrQ-At_33GnpR61k_k0Ujk_RjiJueRCW_zvxduCbcM8rSjCiKAOKPUDGMM9Rm-e3JeI7MTyL4TsxfCcm5z-_XviSfjKRA_U-sGsL753VvY7pP9i_zoae-w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Acupuncture for Chemotherapy-Induced Neutropenia in Patients with Gynecologic Malignancies: A Pilot Randomized, Sham-Controlled Clinical Trial</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Lu, Weidong ; Matulonis, Ursula A. ; Doherty-Gilman, Anne ; Lee, Hang ; Dean-Clower, Elizabeth ; Rosulek, Andrew ; Gibson, Carolyn ; Goodman, Annekathryn ; Davis, Roger B. ; Buring, Julie E. ; Wayne, Peter M. ; Rosenthal, David S. ; Penson, Richard T.</creator><creatorcontrib>Lu, Weidong ; Matulonis, Ursula A. ; Doherty-Gilman, Anne ; Lee, Hang ; Dean-Clower, Elizabeth ; Rosulek, Andrew ; Gibson, Carolyn ; Goodman, Annekathryn ; Davis, Roger B. ; Buring, Julie E. ; Wayne, Peter M. ; Rosenthal, David S. ; Penson, Richard T.</creatorcontrib><description>Objectives:
The objective of this study was to investigate the effect of acupuncture administered during myelosuppressive chemotherapy on white blood cell (WBC) count and absolute neutrophil count (ANC) in patients with ovarian cancer.
Design:
This study is a pilot, randomized, sham-controlled clinical trial. Patients received active acupuncture versus sham acupuncture while undergoing chemotherapy. A standardized acupuncture protocol was employed with manual and electrostimulation. The frequency of treatment was 2–3 times per week for a total of 10 sessions, starting 1 week before the second cycle of chemotherapy.
Setting:
The setting was two outpatient academic centers for patients with cancer.
Subjects:
Twenty-one (21) newly diagnosed and recurrent ovarian cancer patients were the subjects.
Outcome measures:
WBC count, ANC, and plasma granulocyte colony-stimulating factor (G-CSF ) were assessed weekly.
Results:
The median leukocyte value in the acupuncture arm at the first day of the third cycle of chemotherapy was significantly higher than in the control arm after adjusting for baseline value (8600 cells/μL, range: 4800–12,000 versus 4400 cell/μL, range: 2300–10,000) (
p
= 0.046). The incidence of grade 2–4 leukopenia was less in the acupuncture arm than in the sham arm (30% versus 90%;
p
= 0.02). However, the median leukocyte nadir, neutrophil nadir, and recovering ANC were all higher but not statistically significantly different (
p
= 0.116–0.16), after adjusting for baseline differences. There were no statistically significant differences in plasma G-CSF between the two groups.
Conclusions:
We observed clinically relevant trends of higher WBC values during one cycle of chemotherapy in patients with ovarian cancer, which suggests a potential myeloprotective effect of acupuncture. A larger trial is warranted to more definitively determine the efficacy of acupuncture on clinically important outcomes of chemotherapy-induced neutropenia.</description><identifier>ISSN: 1075-5535</identifier><identifier>EISSN: 1557-7708</identifier><identifier>DOI: 10.1089/acm.2008.0589</identifier><identifier>PMID: 19552597</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Acupuncture Therapy ; Adult ; Antineoplastic Agents - adverse effects ; Female ; Humans ; Leukocyte Count ; Middle Aged ; Neutropenia - chemically induced ; Neutropenia - therapy ; Original ; Original Articles ; Ovarian Neoplasms - complications ; Ovarian Neoplasms - drug therapy ; Pilot Projects</subject><ispartof>The journal of alternative and complementary medicine (New York, N.Y.), 2009-07, Vol.15 (7), p.745-753</ispartof><rights>2009, Mary Ann Liebert, Inc.</rights><rights>Copyright 2009, Mary Ann Liebert, Inc. 2009</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-7c177bc1746de68bbc8f8d778fff7540ff9fd9329064c263641e8dab329233d83</citedby><cites>FETCH-LOGICAL-c429t-7c177bc1746de68bbc8f8d778fff7540ff9fd9329064c263641e8dab329233d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19552597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Weidong</creatorcontrib><creatorcontrib>Matulonis, Ursula A.</creatorcontrib><creatorcontrib>Doherty-Gilman, Anne</creatorcontrib><creatorcontrib>Lee, Hang</creatorcontrib><creatorcontrib>Dean-Clower, Elizabeth</creatorcontrib><creatorcontrib>Rosulek, Andrew</creatorcontrib><creatorcontrib>Gibson, Carolyn</creatorcontrib><creatorcontrib>Goodman, Annekathryn</creatorcontrib><creatorcontrib>Davis, Roger B.</creatorcontrib><creatorcontrib>Buring, Julie E.</creatorcontrib><creatorcontrib>Wayne, Peter M.</creatorcontrib><creatorcontrib>Rosenthal, David S.</creatorcontrib><creatorcontrib>Penson, Richard T.</creatorcontrib><title>Acupuncture for Chemotherapy-Induced Neutropenia in Patients with Gynecologic Malignancies: A Pilot Randomized, Sham-Controlled Clinical Trial</title><title>The journal of alternative and complementary medicine (New York, N.Y.)</title><addtitle>J Altern Complement Med</addtitle><description>Objectives:
The objective of this study was to investigate the effect of acupuncture administered during myelosuppressive chemotherapy on white blood cell (WBC) count and absolute neutrophil count (ANC) in patients with ovarian cancer.
Design:
This study is a pilot, randomized, sham-controlled clinical trial. Patients received active acupuncture versus sham acupuncture while undergoing chemotherapy. A standardized acupuncture protocol was employed with manual and electrostimulation. The frequency of treatment was 2–3 times per week for a total of 10 sessions, starting 1 week before the second cycle of chemotherapy.
Setting:
The setting was two outpatient academic centers for patients with cancer.
Subjects:
Twenty-one (21) newly diagnosed and recurrent ovarian cancer patients were the subjects.
Outcome measures:
WBC count, ANC, and plasma granulocyte colony-stimulating factor (G-CSF ) were assessed weekly.
Results:
The median leukocyte value in the acupuncture arm at the first day of the third cycle of chemotherapy was significantly higher than in the control arm after adjusting for baseline value (8600 cells/μL, range: 4800–12,000 versus 4400 cell/μL, range: 2300–10,000) (
p
= 0.046). The incidence of grade 2–4 leukopenia was less in the acupuncture arm than in the sham arm (30% versus 90%;
p
= 0.02). However, the median leukocyte nadir, neutrophil nadir, and recovering ANC were all higher but not statistically significantly different (
p
= 0.116–0.16), after adjusting for baseline differences. There were no statistically significant differences in plasma G-CSF between the two groups.
Conclusions:
We observed clinically relevant trends of higher WBC values during one cycle of chemotherapy in patients with ovarian cancer, which suggests a potential myeloprotective effect of acupuncture. A larger trial is warranted to more definitively determine the efficacy of acupuncture on clinically important outcomes of chemotherapy-induced neutropenia.</description><subject>Acupuncture Therapy</subject><subject>Adult</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Middle Aged</subject><subject>Neutropenia - chemically induced</subject><subject>Neutropenia - therapy</subject><subject>Original</subject><subject>Original Articles</subject><subject>Ovarian Neoplasms - complications</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Pilot Projects</subject><issn>1075-5535</issn><issn>1557-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu3CAUhlHVqkmTLruteIB6ii8Y6KLSyErSSLkpTdcIcxlTYbAwTjR5iD5zGU2UpKtuOOicn-8IfQB8KtGqRJR9FXJcVQjRFcKUvQGHJcakIATRt_mOCC4wrvEB-DDPvxFCTcOq9-CgZBhXmJFD8Gctl2nxMi1RQxMi7AY9hjToKKZtce7VIrWCV3pJMUzaWwGthzciWe3TDB9sGuDZ1msZXNhYCS-FsxsvvLR6_gbX8Ma6kOCt8CqM9lGrL_DnIMaiCz7znMvozllvpXDwLlrhjsE7I9ysPz7VI_Dr9OSu-1FcXJ-dd-uLQjYVSwWRJSF9PppW6Zb2vaSGKkKoMYbgBhnDjGJ1xVDbyKqt26bUVIk-d6q6VrQ-At_33GnpR61k_k0Ujk_RjiJueRCW_zvxduCbcM8rSjCiKAOKPUDGMM9Rm-e3JeI7MTyL4TsxfCcm5z-_XviSfjKRA_U-sGsL753VvY7pP9i_zoae-w</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Lu, Weidong</creator><creator>Matulonis, Ursula A.</creator><creator>Doherty-Gilman, Anne</creator><creator>Lee, Hang</creator><creator>Dean-Clower, Elizabeth</creator><creator>Rosulek, Andrew</creator><creator>Gibson, Carolyn</creator><creator>Goodman, Annekathryn</creator><creator>Davis, Roger B.</creator><creator>Buring, Julie E.</creator><creator>Wayne, Peter M.</creator><creator>Rosenthal, David S.</creator><creator>Penson, Richard T.</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20090701</creationdate><title>Acupuncture for Chemotherapy-Induced Neutropenia in Patients with Gynecologic Malignancies: A Pilot Randomized, Sham-Controlled Clinical Trial</title><author>Lu, Weidong ; Matulonis, Ursula A. ; Doherty-Gilman, Anne ; Lee, Hang ; Dean-Clower, Elizabeth ; Rosulek, Andrew ; Gibson, Carolyn ; Goodman, Annekathryn ; Davis, Roger B. ; Buring, Julie E. ; Wayne, Peter M. ; Rosenthal, David S. ; Penson, Richard T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-7c177bc1746de68bbc8f8d778fff7540ff9fd9329064c263641e8dab329233d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acupuncture Therapy</topic><topic>Adult</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Middle Aged</topic><topic>Neutropenia - chemically induced</topic><topic>Neutropenia - therapy</topic><topic>Original</topic><topic>Original Articles</topic><topic>Ovarian Neoplasms - complications</topic><topic>Ovarian Neoplasms - drug therapy</topic><topic>Pilot Projects</topic><toplevel>online_resources</toplevel><creatorcontrib>Lu, Weidong</creatorcontrib><creatorcontrib>Matulonis, Ursula A.</creatorcontrib><creatorcontrib>Doherty-Gilman, Anne</creatorcontrib><creatorcontrib>Lee, Hang</creatorcontrib><creatorcontrib>Dean-Clower, Elizabeth</creatorcontrib><creatorcontrib>Rosulek, Andrew</creatorcontrib><creatorcontrib>Gibson, Carolyn</creatorcontrib><creatorcontrib>Goodman, Annekathryn</creatorcontrib><creatorcontrib>Davis, Roger B.</creatorcontrib><creatorcontrib>Buring, Julie E.</creatorcontrib><creatorcontrib>Wayne, Peter M.</creatorcontrib><creatorcontrib>Rosenthal, David S.</creatorcontrib><creatorcontrib>Penson, Richard T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of alternative and complementary medicine (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Weidong</au><au>Matulonis, Ursula A.</au><au>Doherty-Gilman, Anne</au><au>Lee, Hang</au><au>Dean-Clower, Elizabeth</au><au>Rosulek, Andrew</au><au>Gibson, Carolyn</au><au>Goodman, Annekathryn</au><au>Davis, Roger B.</au><au>Buring, Julie E.</au><au>Wayne, Peter M.</au><au>Rosenthal, David S.</au><au>Penson, Richard T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acupuncture for Chemotherapy-Induced Neutropenia in Patients with Gynecologic Malignancies: A Pilot Randomized, Sham-Controlled Clinical Trial</atitle><jtitle>The journal of alternative and complementary medicine (New York, N.Y.)</jtitle><addtitle>J Altern Complement Med</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>15</volume><issue>7</issue><spage>745</spage><epage>753</epage><pages>745-753</pages><issn>1075-5535</issn><eissn>1557-7708</eissn><abstract>Objectives:
The objective of this study was to investigate the effect of acupuncture administered during myelosuppressive chemotherapy on white blood cell (WBC) count and absolute neutrophil count (ANC) in patients with ovarian cancer.
Design:
This study is a pilot, randomized, sham-controlled clinical trial. Patients received active acupuncture versus sham acupuncture while undergoing chemotherapy. A standardized acupuncture protocol was employed with manual and electrostimulation. The frequency of treatment was 2–3 times per week for a total of 10 sessions, starting 1 week before the second cycle of chemotherapy.
Setting:
The setting was two outpatient academic centers for patients with cancer.
Subjects:
Twenty-one (21) newly diagnosed and recurrent ovarian cancer patients were the subjects.
Outcome measures:
WBC count, ANC, and plasma granulocyte colony-stimulating factor (G-CSF ) were assessed weekly.
Results:
The median leukocyte value in the acupuncture arm at the first day of the third cycle of chemotherapy was significantly higher than in the control arm after adjusting for baseline value (8600 cells/μL, range: 4800–12,000 versus 4400 cell/μL, range: 2300–10,000) (
p
= 0.046). The incidence of grade 2–4 leukopenia was less in the acupuncture arm than in the sham arm (30% versus 90%;
p
= 0.02). However, the median leukocyte nadir, neutrophil nadir, and recovering ANC were all higher but not statistically significantly different (
p
= 0.116–0.16), after adjusting for baseline differences. There were no statistically significant differences in plasma G-CSF between the two groups.
Conclusions:
We observed clinically relevant trends of higher WBC values during one cycle of chemotherapy in patients with ovarian cancer, which suggests a potential myeloprotective effect of acupuncture. A larger trial is warranted to more definitively determine the efficacy of acupuncture on clinically important outcomes of chemotherapy-induced neutropenia.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>19552597</pmid><doi>10.1089/acm.2008.0589</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1075-5535 |
| ispartof | The journal of alternative and complementary medicine (New York, N.Y.), 2009-07, Vol.15 (7), p.745-753 |
| issn | 1075-5535 1557-7708 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2875080 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Acupuncture Therapy Adult Antineoplastic Agents - adverse effects Female Humans Leukocyte Count Middle Aged Neutropenia - chemically induced Neutropenia - therapy Original Original Articles Ovarian Neoplasms - complications Ovarian Neoplasms - drug therapy Pilot Projects |
| title | Acupuncture for Chemotherapy-Induced Neutropenia in Patients with Gynecologic Malignancies: A Pilot Randomized, Sham-Controlled Clinical Trial |
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