Selective α7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis

Background and purpose:  In various models vagus nerve activation has been shown to ameliorate intestinal inflammation, via nicotinic acetylcholine receptors (nAChRs) expressed on immune cells. As the α7 nAChR has been put forward to mediate this effect, we studied the effect of nicotine and two sel...

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Veröffentlicht in:	British journal of pharmacology 2010-05, Vol.160 (2), p.322-333
Hauptverfasser:	Snoek, Susanne A, Verstege, Marleen I, van der Zanden, Esmerij P, Deeks, Nigel, Bulmer, David C, Skynner, Michael, Lee, Kevin, te Velde, Anje A, Boeckxstaens, Guy E, de Jonge, Wouter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences colitis macrophages Medical sciences nicotine Pharmacology. Drug treatments Research Papers vagus nerve α7 nicotinic acetylcholine receptor
Online-Zugang:	Volltext
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