Increased brain damage after ischaemic stroke in mice lacking the chemokine receptor CCR5

Background and purpose: The chemokine receptor CCR5 is well known for its function in immune cells; however, it is also expressed in the brain, where its specific role remains to be elucidated. Because genetic factors may influence the risk of developing cerebral ischaemia or affect its clinical ou...

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Veröffentlicht in:	British journal of pharmacology 2010-05, Vol.160 (2), p.311-321
Hauptverfasser:	Sorce, S, Bonnefont, J, Julien, S, Marq‐Lin, N, Rodriguez, I, Dubois‐Dauphin, M, Krause, KH
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Animals Astrocytes Astrocytes - metabolism Biological and medical sciences brain Brain injury Brain Ischemia - physiopathology CCR5 CCR5 protein Cerebral blood flow cerebral ischaemia chemokine receptor Chemokine receptors Chemokines Disease Models, Animal Drugs Genetic factors genetics Infarction, Middle Cerebral Artery - pathology Ischemia Leukocytes (neutrophilic) Male Medical research Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Microglia Microglia - metabolism Motor Activity Neurology neuronal death Neutrophils - metabolism Pharmacology. Drug treatments Receptors, CCR5 - genetics Research Papers Rodents Severity of Illness Index Stroke Time Factors Vascular diseases and vascular malformations of the nervous system
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