Dietary Na⁺ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y₂-receptor tone

Apical release of ATP and UTP can activate P2Y₂ receptors in the aldosterone-sensitive distal nephron (ASDN) and inhibit the open probability (Po) of the epithelial sodium channel (ENaC). Little is known, however, about the regulation and physiological relevance of this system. Patch-clamp studies i...

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Veröffentlicht in:	The FASEB journal 2010-06, Vol.24 (6), p.2056-2065
Hauptverfasser:	Pochynyuk, Oleh, Rieg, Timo, Bugaj, Vladislav, Schroth, Jana, Fridman, Alla, Boss, Gerry R, Insel, Paul A, Stockand, James D, Vallon, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - urine aldosterone Aldosterone - pharmacology Animals ATP blood pressure Blood Pressure - drug effects Cells, Cultured distal nephron Electrophysiology Epithelial Sodium Channels - metabolism Homeostasis - drug effects Kidney - cytology Kidney - drug effects Kidney - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mineralocorticoids - pharmacology Nephrons - cytology Nephrons - drug effects Nephrons - metabolism nucleotide receptors Patch-Clamp Techniques Receptors, Purinergic P2 - physiology Receptors, Purinergic P2Y2 Research Communications Signal Transduction Sodium, Dietary - administration & dosage Sodium, Dietary - pharmacology Uridine Triphosphate - urine
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