DNA bending induced by carbocyclic sugar analogs constrained to the north conformation

DNA bending caused by introduction of carbocyclic sugars constrained to the north conformation was studied, using explicit solvent molecular dynamic (MD) simulations. The native Drew–Dickerson (DD) dodecamer and its three modifications containing north carbocyclic sugars in the 7th (T7*), 8th (T8*)...

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Veröffentlicht in:	Biopolymers 2007-04, Vol.85 (5‐6), p.438-449
Hauptverfasser:	Macias, Alba T., Banavali, Nilesh K., MacKerell, Alexander D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pairing Base Sequence Carbohydrate Conformation conformation DNA - chemistry DNA‐protein interaction MD simulation Models, Molecular Molecular Sequence Data Nucleic Acid Conformation nucleic acids Nucleotides - chemistry oligonucleotides Oligonucleotides - chemistry Structure-Activity Relationship
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