Increased Insertion of Glutamate Receptor 2-Lacking α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid (AMPA) Receptors at Hippocampal Synapses upon Repeated Morphine Administration

Evidence suggests that the long-term adaptations in the hippocampus after repeated drug treatment may parallel its role during memory formation. The neuroplasticity that subserves learning and memory is also believed to underlie addictive processes. We have reported previously that repeated morphine...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular pharmacology 2010-05, Vol.77 (5), p.874-883
Hauptverfasser:	Billa, Sophie K., Liu, Jie, Bjorklund, Nicole L., Sinha, Namita, Fu, Yu, Shinnick-Gallagher, Patricia, Morón, Jose A.
Format:	Artikel
Sprache:	eng
Schlagworte:	(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride 2-amino-5-phosphonovalerate ACSF AMPA AMPAR analysis of variance Animals ANOVA artificial cerebral spinal fluid CGP55845 d-APV EPSC excitatory postsynaptic currents Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology extracellular field excitatory postsynaptic potential fEPSP fiber volley GABA Antagonists - pharmacology HFS high-frequency stimulation immunoprecipitation Joro spider toxin JST LFS long-term depression long-term potentiation Long-Term Potentiation - drug effects Long-Term Potentiation - physiology low-frequency stimulation LTD LTP Male Mice Mice, Inbred C57BL Mice, Knockout Morphine - pharmacology N-(2,6-dimethylphenylcarbamoylmethyl)triethylammonium N-methyl-d-aspartate N-methyl-d-aspartate receptor NMDA NMDAR paired-pulse facilitation philanthotoxin Phosphinic Acids - pharmacology Phosphorylation Phtx picrotoxin Picrotoxin - pharmacology postsynaptic density PPF Propanolamines - pharmacology Protein Subunits - drug effects Protein Subunits - genetics PSD PTX QX314 Receptors, AMPA - biosynthesis Receptors, AMPA - deficiency Receptors, AMPA - drug effects Receptors, AMPA - genetics Receptors, AMPA - physiology rectification index Synapses - drug effects Synapses - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology ventral tegmental area VTA α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!