A Mouse Model of Severe Halothane Hepatitis Based on Human Risk FactorsS

Halothane (2-bromo-2-chloro-1,1,1-trifluoro-ethane) is an inhaled anesthetic that induces severe, idiosyncratic liver injury, i.e., “halothane hepatitis,” in approximately 1 in 20,000 human patients. We used known human risk factors (female sex, adult age, and genetics) as well as probable risk fact...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2010-05, Vol.333 (2), p.364-372
Hauptverfasser:	Dugan, Christine M., MacDonald, Allen E., Roth, Robert A., Ganey, Patricia E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Toxicology
Online-Zugang:	Volltext
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