Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast

We show that fluorescence lifetime is a powerful contrast mechanism that can enhance the whole-body imaging of fluorescent proteins (FPs), in the presence of background tissue autofluorescence (AF). The nonexponential AF decay is characterized from time-domain (TD) measurements on multiple nude mice...

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Veröffentlicht in:	Optics letters 2009-07, Vol.34 (13), p.2066-2068
Hauptverfasser:	KUMAR, Anand T. N, CHUNG, Euiheon, RAYMOND, Scott B, VAN DE WATER, Jeroen A. J. M, SHAH, Khalid, FUKUMURA, Dai, JAIN, Rakesh K, BACSKAI, Brian J, BOAS, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line, Tumor Feasibility Studies Feathers Fluorescence Fundamental and applied biological sciences. Psychology General aspects, investigation technics, apparatus Humans Luminescent Proteins - metabolism Mice Time Factors Tissues, organs and organisms biophysics
Online-Zugang:	Volltext
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