Heme-responsive DNA Binding by the Global Iron Regulator Irr from Rhizobium leguminosarum

Heme, a physiologically crucial form of iron, is a cofactor for a very wide range of proteins and enzymes. These include DNA regulatory proteins in which heme is a sensor to which an analyte molecule binds, effecting a change in the DNA binding affinity of the regulator. Given that heme, and more ge...

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Veröffentlicht in:	The Journal of biological chemistry 2010-05, Vol.285 (21), p.16023-16031
Hauptverfasser:	Singleton, Chloe, White, Gaye F., Todd, Jonathan D., Marritt, Sophie J., Cheesman, Myles R., Johnston, Andrew W.B., Le Brun, Nick E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Bacterial Proteins - genetics Bacterial Proteins - metabolism Bradyrhizobium - genetics Bradyrhizobium - metabolism Bradyrhizobium japonicum DNA, Bacterial - genetics DNA, Bacterial - metabolism DNA/Protein Interaction DNA/Transcription Gene Regulation Heme - genetics Heme - metabolism Metals/Iron Microbiology Mutation Operator Regions, Genetic - physiology Protein Binding - physiology Protein/Chemistry Protein/Heme Protein/Iron Rhizobium leguminosarum Rhizobium leguminosarum - genetics Rhizobium leguminosarum - metabolism Species Specificity Transcription Factors - genetics Transcription Factors - metabolism Transcription/Regulation
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