Distinct roles of the three Akt isoforms in lactogenic differentiation and involution

The three Akt isoforms differ in their ability to transduce oncogenic signals initiated by the Neu and PyMT oncogenes in mammary epithelia. As a result, ablation of Akt1 inhibits and ablation of Akt2 accelerates mammary tumor development by both oncogenes, while ablation of Akt3 is phenotypically al...

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Veröffentlicht in:	Journal of cellular physiology 2008-11, Vol.217 (2), p.468-477
Hauptverfasser:	Maroulakou, Ioanna G., Oemler, William, Naber, Stephen P., Klebba, Ina, Kuperwasser, Charlotte, Tsichlis, Philip N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Differentiation Cell Proliferation Cell Survival Epithelial Cells - enzymology Epithelial Cells - transplantation Female Genotype Isoenzymes Lactation Mammary Glands, Animal - enzymology Mammary Glands, Animal - growth & development Mammary Glands, Animal - transplantation Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Knockout Mice, SCID Milk - metabolism Phenotype Phosphorylation Pregnancy Proto-Oncogene Proteins c-akt - deficiency Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Signal Transduction STAT5 Transcription Factor - metabolism Time Factors
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