Trends in incidence of pneumococcal disease before introduction of conjugate vaccine: South West England, 1996–2005
Introduction of pneumococcal conjugate and polysaccharide vaccines into the United Kingdom's routine immunization programmes is expected to change the epidemiology of invasive pneumococcal disease (IPD). We have documented the epidemiology of IPD in an English region (South West) with high-qual...
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| Veröffentlicht in: | Epidemiology and infection 2008-08, Vol.136 (8), p.1096-1102 |
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| creator | IHEKWEAZU, C. A. DANCE, D. A. B. PEBODY, R. GEORGE, R. C. SMITH, M. D. WAIGHT, P. CHRISTENSEN, H. CARTWRIGHT, K. A. V. STUART, J. M. |
| description | Introduction of pneumococcal conjugate and polysaccharide vaccines into the United Kingdom's routine immunization programmes is expected to change the epidemiology of invasive pneumococcal disease (IPD). We have documented the epidemiology of IPD in an English region (South West) with high-quality surveillance data before these programmes were established. We analysed data on isolates of Streptococcus pneumoniae from blood and CSF between 1996 and 2005 from microbiology laboratories in the South West that were reported and/or referred for serotyping to the Health Protection Agency Centre for Infections. The mean annual incidence of IPD increased from 11·2/100 000 in 1996 to 13·6/100 000 in 2005 (P |
| doi_str_mv | 10.1017/S0950268807009715 |
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A. ; DANCE, D. A. B. ; PEBODY, R. ; GEORGE, R. C. ; SMITH, M. D. ; WAIGHT, P. ; CHRISTENSEN, H. ; CARTWRIGHT, K. A. V. ; STUART, J. M.</creator><creatorcontrib>IHEKWEAZU, C. A. ; DANCE, D. A. B. ; PEBODY, R. ; GEORGE, R. C. ; SMITH, M. D. ; WAIGHT, P. ; CHRISTENSEN, H. ; CARTWRIGHT, K. A. V. ; STUART, J. M. ; South West Pneumococcus Study Group</creatorcontrib><description>Introduction of pneumococcal conjugate and polysaccharide vaccines into the United Kingdom's routine immunization programmes is expected to change the epidemiology of invasive pneumococcal disease (IPD). We have documented the epidemiology of IPD in an English region (South West) with high-quality surveillance data before these programmes were established. We analysed data on isolates of Streptococcus pneumoniae from blood and CSF between 1996 and 2005 from microbiology laboratories in the South West that were reported and/or referred for serotyping to the Health Protection Agency Centre for Infections. The mean annual incidence of IPD increased from 11·2/100 000 in 1996 to 13·6/100 000 in 2005 (P<0·04). After adjusting for annual blood-culture sampling rates in hospitals serving the same catchment populations, an increase in annual incidence of IPD was no longer observed (P=1·0). Variation in overall incidence between laboratories could also be explained by variation in blood culture rates. The proportion of disease caused by serotypes 6B, 9V and 14 decreased significantly (P=0·001, P=0·007, and P=0·027 respectively) whereas that caused by serotype 4, 7F and 1 increased (P=0·001, P=0·003, and P<0·001 respectively) between 2000 and 2005. The level of penicillin non-susceptibility and resistance to erythromycin remained stable (2% and 12% respectively). This study provides an important baseline to assess the impact of changing vaccination programmes on the epidemiology of IPD, thus informing future use of pneumococcal vaccines.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268807009715</identifier><identifier>PMID: 17961282</identifier><identifier>CODEN: EPINEU</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Age groups ; Aged ; Aged, 80 and over ; Antimicrobial agents ; Applied microbiology ; At risk youth ; Bacterial diseases ; Biological and medical sciences ; Blood ; Child ; Child, Preschool ; Conjugate vaccines ; Disease prevention ; Disease resistance ; Drug Resistance, Bacterial ; England - epidemiology ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Heptavalent Pneumococcal Conjugate Vaccine ; Human bacterial diseases ; Humans ; Incidence ; Infant ; Infant, Newborn ; Infections ; Infectious diseases ; Laboratories ; Male ; Medical sciences ; Meningitis ; Meningococcal Vaccines ; Microbiology ; Middle Aged ; Original Papers ; Pneumococcal Infections - epidemiology ; Pneumococcal Vaccines ; Population Surveillance ; Serotyping ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Streptococcus infections ; Streptococcus pneumoniae ; Surveillance ; Trends ; Vaccination ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, Conjugate</subject><ispartof>Epidemiology and infection, 2008-08, Vol.136 (8), p.1096-1102</ispartof><rights>Copyright © 2007 Cambridge University Press</rights><rights>Copyright 2008 Cambridge University Press</rights><rights>2008 INIST-CNRS</rights><rights>Copyright © 2007 Cambridge University Press 2007 Cambridge University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-90277f58d2fd9854f4e8c483a06d4bdc512a90b189b2c99761cd1892feec82de3</citedby><cites>FETCH-LOGICAL-c558t-90277f58d2fd9854f4e8c483a06d4bdc512a90b189b2c99761cd1892feec82de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30221582$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30221582$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,728,781,785,804,886,27929,27930,53796,53798,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20487030$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17961282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IHEKWEAZU, C. A.</creatorcontrib><creatorcontrib>DANCE, D. A. B.</creatorcontrib><creatorcontrib>PEBODY, R.</creatorcontrib><creatorcontrib>GEORGE, R. C.</creatorcontrib><creatorcontrib>SMITH, M. D.</creatorcontrib><creatorcontrib>WAIGHT, P.</creatorcontrib><creatorcontrib>CHRISTENSEN, H.</creatorcontrib><creatorcontrib>CARTWRIGHT, K. A. V.</creatorcontrib><creatorcontrib>STUART, J. M.</creatorcontrib><creatorcontrib>South West Pneumococcus Study Group</creatorcontrib><title>Trends in incidence of pneumococcal disease before introduction of conjugate vaccine: South West England, 1996–2005</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>Introduction of pneumococcal conjugate and polysaccharide vaccines into the United Kingdom's routine immunization programmes is expected to change the epidemiology of invasive pneumococcal disease (IPD). We have documented the epidemiology of IPD in an English region (South West) with high-quality surveillance data before these programmes were established. We analysed data on isolates of Streptococcus pneumoniae from blood and CSF between 1996 and 2005 from microbiology laboratories in the South West that were reported and/or referred for serotyping to the Health Protection Agency Centre for Infections. The mean annual incidence of IPD increased from 11·2/100 000 in 1996 to 13·6/100 000 in 2005 (P<0·04). After adjusting for annual blood-culture sampling rates in hospitals serving the same catchment populations, an increase in annual incidence of IPD was no longer observed (P=1·0). Variation in overall incidence between laboratories could also be explained by variation in blood culture rates. The proportion of disease caused by serotypes 6B, 9V and 14 decreased significantly (P=0·001, P=0·007, and P=0·027 respectively) whereas that caused by serotype 4, 7F and 1 increased (P=0·001, P=0·003, and P<0·001 respectively) between 2000 and 2005. The level of penicillin non-susceptibility and resistance to erythromycin remained stable (2% and 12% respectively). This study provides an important baseline to assess the impact of changing vaccination programmes on the epidemiology of IPD, thus informing future use of pneumococcal vaccines.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age groups</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antimicrobial agents</subject><subject>Applied microbiology</subject><subject>At risk youth</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Conjugate vaccines</subject><subject>Disease prevention</subject><subject>Disease resistance</subject><subject>Drug Resistance, Bacterial</subject><subject>England - epidemiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heptavalent Pneumococcal Conjugate Vaccine</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meningitis</subject><subject>Meningococcal Vaccines</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Original Papers</subject><subject>Pneumococcal Infections - epidemiology</subject><subject>Pneumococcal Vaccines</subject><subject>Population Surveillance</subject><subject>Serotyping</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Streptococcus infections</subject><subject>Streptococcus pneumoniae</subject><subject>Surveillance</subject><subject>Trends</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, Conjugate</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kd-K1DAYxYMo7jj6AF4oRdArq0natIkXggzr-mdBZUe9DGnydTZjm4xJu-id7-Ab-iSmTpn1D0IghPPLxznfQeg2wY8IJvXjMywYphXnuMZY1IRdQQtSViIvSyyuosUk55N-hG7EuMUJory-jo5ILSpCOV2gcR3AmZhZl462BpyGzLfZzsHYe-21Vl1mbAQVIWug9QESOARvRj1Y7yZWe7cdN2qA7EJpbR08yc78OJxnHyEO2bHbdMqZhxkRovrx7TvFmN1E11rVRbg130v0_vnxevUiP31z8nL17DTXjPEhF5jWdcu4oa0RnJVtCVyXvFC4MmVjNCNUCdwQLhqqhagrok160BZAc2qgWKKn-7m7senBaEjOVSd3wfYqfJVeWfmn4uy53PgLmdaEuWBpwIN5QPCfxxRH9jZq6FIi8GOUVVpoSQRO4L2_wK0fg0vhJMWsFIQm30tE9pAOPsYA7cEJwXJqVP7TaPpz9_cIlz_mChNwfwZUTGW1QaUe44GjuExZisnhnT23jYMPB73AlBL2a06-120c4MtBV-GTrOqiZrI6eZdo8Wr19sNavk58MYdRfROs2cBl5P_H-QnautGi</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>IHEKWEAZU, C. 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A. ; DANCE, D. A. B. ; PEBODY, R. ; GEORGE, R. C. ; SMITH, M. D. ; WAIGHT, P. ; CHRISTENSEN, H. ; CARTWRIGHT, K. A. V. ; STUART, J. 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A.</au><au>DANCE, D. A. B.</au><au>PEBODY, R.</au><au>GEORGE, R. C.</au><au>SMITH, M. D.</au><au>WAIGHT, P.</au><au>CHRISTENSEN, H.</au><au>CARTWRIGHT, K. A. V.</au><au>STUART, J. M.</au><aucorp>South West Pneumococcus Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trends in incidence of pneumococcal disease before introduction of conjugate vaccine: South West England, 1996–2005</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>136</volume><issue>8</issue><spage>1096</spage><epage>1102</epage><pages>1096-1102</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><coden>EPINEU</coden><abstract>Introduction of pneumococcal conjugate and polysaccharide vaccines into the United Kingdom's routine immunization programmes is expected to change the epidemiology of invasive pneumococcal disease (IPD). We have documented the epidemiology of IPD in an English region (South West) with high-quality surveillance data before these programmes were established. We analysed data on isolates of Streptococcus pneumoniae from blood and CSF between 1996 and 2005 from microbiology laboratories in the South West that were reported and/or referred for serotyping to the Health Protection Agency Centre for Infections. The mean annual incidence of IPD increased from 11·2/100 000 in 1996 to 13·6/100 000 in 2005 (P<0·04). After adjusting for annual blood-culture sampling rates in hospitals serving the same catchment populations, an increase in annual incidence of IPD was no longer observed (P=1·0). Variation in overall incidence between laboratories could also be explained by variation in blood culture rates. The proportion of disease caused by serotypes 6B, 9V and 14 decreased significantly (P=0·001, P=0·007, and P=0·027 respectively) whereas that caused by serotype 4, 7F and 1 increased (P=0·001, P=0·003, and P<0·001 respectively) between 2000 and 2005. The level of penicillin non-susceptibility and resistance to erythromycin remained stable (2% and 12% respectively). This study provides an important baseline to assess the impact of changing vaccination programmes on the epidemiology of IPD, thus informing future use of pneumococcal vaccines.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>17961282</pmid><doi>10.1017/S0950268807009715</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Epidemiology and infection, 2008-08, Vol.136 (8), p.1096-1102 |
| issn | 0950-2688 1469-4409 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central |
| subjects | Adolescent Adult Age groups Aged Aged, 80 and over Antimicrobial agents Applied microbiology At risk youth Bacterial diseases Biological and medical sciences Blood Child Child, Preschool Conjugate vaccines Disease prevention Disease resistance Drug Resistance, Bacterial England - epidemiology Epidemiology Female Fundamental and applied biological sciences. Psychology Heptavalent Pneumococcal Conjugate Vaccine Human bacterial diseases Humans Incidence Infant Infant, Newborn Infections Infectious diseases Laboratories Male Medical sciences Meningitis Meningococcal Vaccines Microbiology Middle Aged Original Papers Pneumococcal Infections - epidemiology Pneumococcal Vaccines Population Surveillance Serotyping Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus infections Streptococcus pneumoniae Surveillance Trends Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Conjugate |
| title | Trends in incidence of pneumococcal disease before introduction of conjugate vaccine: South West England, 1996–2005 |
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