Epidemiology and outcome of sepsis in a tertiary-care hospital in a developing country
Sepsis continues to have a substantial mortality and morbidity despite advances in the diagnosis and management of this condition. We retrospectively analysed hospital charts of patients diagnosed to have sepsis between January 2002 and June 2003. Demographic characteristics of patients, microbiolog...
Gespeichert in:
| Veröffentlicht in: | Epidemiology and infection 2006-04, Vol.134 (2), p.315-322 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 322 |
|---|---|
| container_issue | 2 |
| container_start_page | 315 |
| container_title | Epidemiology and infection |
| container_volume | 134 |
| creator | TANRIOVER, M. D. GUVEN, G. S. SEN, D. UNAL, S. UZUN, O. |
| description | Sepsis continues to have a substantial mortality and morbidity despite advances in the diagnosis and management of this condition. We retrospectively analysed hospital charts of patients diagnosed to have sepsis between January 2002 and June 2003. Demographic characteristics of patients, microbiological findings and predictors of survival were evaluated. Sixty-nine sepsis episodes that occurred in 63 patients were analysed. The most common underlying diseases were hypertension, malignancies and diabetes mellitus. Renal insufficiency, respiratory distress and disseminated intravascular coagulation developed in 52·2, 30·4 and 30·4% of the episodes respectively; 47·7% of the blood cultures yielded an organism. Gram-negative bacteria were the predominant microorganisms (65·9%). Fifty-five patients (87·3%) died. Mechanical ventilation and underlying renal disease were significant determinants of mortality. In conclusion, Gram-negative bacteria remain the major pathogens in sepsis. The mortality remains very high, and a change in the clinical approach to the septic patient should be employed to improve the outcome. |
| doi_str_mv | 10.1017/S0950268805004978 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2870389</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0950268805004978</cupid><jstor_id>3865635</jstor_id><sourcerecordid>3865635</sourcerecordid><originalsourceid>FETCH-LOGICAL-c588t-4cf32138379594ba56f683e7954bbbba7b76034886b1308357da13a5d638beaa3</originalsourceid><addsrcrecordid>eNqFkV2L1DAUhoMo7uzqDxBEiqB31aT57I2gy7oqqyK7ehtO03Q2Y9vUpF12_r0ZWmb8QMxNCO9zTs77HoQeEfyCYCJfXuKS40IohTnGrJTqDloRJsqcMVzeRaudnO_0I3Qc4wZjXBZK3kdHRLASEypW6NvZ4GrbOd_69TaDvs78NBrf2cw3WbRDdDFzfQbZaMPoIGxzA8Fm1z4OboR21mp7Y1s_uH6dGT_1Y9g-QPcaaKN9uNwn6Ovbs6vTd_nF5_P3p68vcsOVGnNmGloQqqgseckq4KIRitr0YlU6ICspMGVKiYpQrCiXNRAKvBZUVRaAnqBXc99hqjpbG5s-h1YPwXVpVu3B6d-V3l3rtb_RKQdMVZkaPF8aBP9jsnHUnYvGti301k9RCylkSWjxX5CkaBnlOIFP_wA3fgp9SkEXmDNFCsYSRGbIBB9jsM1-ZIL1brf6r92mmie_ej1ULMtMwLMFgGigbQL0xsUDJznZuU7c45nbxNGHvU6V4ILyJOez7OJob_cyhO8pDSq5Fudf9IfLT-pKveH6Y-Lp4gW6Krh6bQ-O_-3mJ9_r06I</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>205481244</pqid></control><display><type>article</type><title>Epidemiology and outcome of sepsis in a tertiary-care hospital in a developing country</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><creator>TANRIOVER, M. D. ; GUVEN, G. S. ; SEN, D. ; UNAL, S. ; UZUN, O.</creator><creatorcontrib>TANRIOVER, M. D. ; GUVEN, G. S. ; SEN, D. ; UNAL, S. ; UZUN, O.</creatorcontrib><description>Sepsis continues to have a substantial mortality and morbidity despite advances in the diagnosis and management of this condition. We retrospectively analysed hospital charts of patients diagnosed to have sepsis between January 2002 and June 2003. Demographic characteristics of patients, microbiological findings and predictors of survival were evaluated. Sixty-nine sepsis episodes that occurred in 63 patients were analysed. The most common underlying diseases were hypertension, malignancies and diabetes mellitus. Renal insufficiency, respiratory distress and disseminated intravascular coagulation developed in 52·2, 30·4 and 30·4% of the episodes respectively; 47·7% of the blood cultures yielded an organism. Gram-negative bacteria were the predominant microorganisms (65·9%). Fifty-five patients (87·3%) died. Mechanical ventilation and underlying renal disease were significant determinants of mortality. In conclusion, Gram-negative bacteria remain the major pathogens in sepsis. The mortality remains very high, and a change in the clinical approach to the septic patient should be employed to improve the outcome.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268805004978</identifier><identifier>PMID: 16490136</identifier><identifier>CODEN: EPINEU</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Aged ; Bacteria ; Bacterial diseases ; Bacterial sepsis ; Biological and medical sciences ; Blood ; Blood pressure ; Developing Countries ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Gram negative bacteria ; Gram-positive bacteria ; Health outcomes ; Hospitals ; Hospitals, University - statistics & numerical data ; Human bacterial diseases ; Humans ; Incidence ; Infections ; Infectious diseases ; Intensive care units ; Kidney Diseases - complications ; LDCs ; Male ; Medical Records ; Medical sciences ; Medicine ; Microbiology ; Microorganisms ; Middle Aged ; Mortality ; Pathogens ; Patients ; Prognosis ; Respiration, Artificial ; Retrospective Studies ; Sepsis ; Sepsis - mortality ; Sepsis - pathology ; Sepsis - therapy ; Septic shock ; Survival Analysis ; Turkey - epidemiology ; Ventilators</subject><ispartof>Epidemiology and infection, 2006-04, Vol.134 (2), p.315-322</ispartof><rights>2005 Cambridge University Press</rights><rights>Copyright 2006 Cambridge University Press</rights><rights>2006 INIST-CNRS</rights><rights>Cambridge University Press 2005 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-4cf32138379594ba56f683e7954bbbba7b76034886b1308357da13a5d638beaa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3865635$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3865635$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17518703$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16490136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TANRIOVER, M. D.</creatorcontrib><creatorcontrib>GUVEN, G. S.</creatorcontrib><creatorcontrib>SEN, D.</creatorcontrib><creatorcontrib>UNAL, S.</creatorcontrib><creatorcontrib>UZUN, O.</creatorcontrib><title>Epidemiology and outcome of sepsis in a tertiary-care hospital in a developing country</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>Sepsis continues to have a substantial mortality and morbidity despite advances in the diagnosis and management of this condition. We retrospectively analysed hospital charts of patients diagnosed to have sepsis between January 2002 and June 2003. Demographic characteristics of patients, microbiological findings and predictors of survival were evaluated. Sixty-nine sepsis episodes that occurred in 63 patients were analysed. The most common underlying diseases were hypertension, malignancies and diabetes mellitus. Renal insufficiency, respiratory distress and disseminated intravascular coagulation developed in 52·2, 30·4 and 30·4% of the episodes respectively; 47·7% of the blood cultures yielded an organism. Gram-negative bacteria were the predominant microorganisms (65·9%). Fifty-five patients (87·3%) died. Mechanical ventilation and underlying renal disease were significant determinants of mortality. In conclusion, Gram-negative bacteria remain the major pathogens in sepsis. The mortality remains very high, and a change in the clinical approach to the septic patient should be employed to improve the outcome.</description><subject>Adult</subject><subject>Aged</subject><subject>Bacteria</subject><subject>Bacterial diseases</subject><subject>Bacterial sepsis</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood pressure</subject><subject>Developing Countries</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gram negative bacteria</subject><subject>Gram-positive bacteria</subject><subject>Health outcomes</subject><subject>Hospitals</subject><subject>Hospitals, University - statistics & numerical data</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Intensive care units</subject><subject>Kidney Diseases - complications</subject><subject>LDCs</subject><subject>Male</subject><subject>Medical Records</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Respiration, Artificial</subject><subject>Retrospective Studies</subject><subject>Sepsis</subject><subject>Sepsis - mortality</subject><subject>Sepsis - pathology</subject><subject>Sepsis - therapy</subject><subject>Septic shock</subject><subject>Survival Analysis</subject><subject>Turkey - epidemiology</subject><subject>Ventilators</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkV2L1DAUhoMo7uzqDxBEiqB31aT57I2gy7oqqyK7ehtO03Q2Y9vUpF12_r0ZWmb8QMxNCO9zTs77HoQeEfyCYCJfXuKS40IohTnGrJTqDloRJsqcMVzeRaudnO_0I3Qc4wZjXBZK3kdHRLASEypW6NvZ4GrbOd_69TaDvs78NBrf2cw3WbRDdDFzfQbZaMPoIGxzA8Fm1z4OboR21mp7Y1s_uH6dGT_1Y9g-QPcaaKN9uNwn6Ovbs6vTd_nF5_P3p68vcsOVGnNmGloQqqgseckq4KIRitr0YlU6ICspMGVKiYpQrCiXNRAKvBZUVRaAnqBXc99hqjpbG5s-h1YPwXVpVu3B6d-V3l3rtb_RKQdMVZkaPF8aBP9jsnHUnYvGti301k9RCylkSWjxX5CkaBnlOIFP_wA3fgp9SkEXmDNFCsYSRGbIBB9jsM1-ZIL1brf6r92mmie_ej1ULMtMwLMFgGigbQL0xsUDJznZuU7c45nbxNGHvU6V4ILyJOez7OJob_cyhO8pDSq5Fudf9IfLT-pKveH6Y-Lp4gW6Krh6bQ-O_-3mJ9_r06I</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>TANRIOVER, M. D.</creator><creator>GUVEN, G. S.</creator><creator>SEN, D.</creator><creator>UNAL, S.</creator><creator>UZUN, O.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T7</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060401</creationdate><title>Epidemiology and outcome of sepsis in a tertiary-care hospital in a developing country</title><author>TANRIOVER, M. D. ; GUVEN, G. S. ; SEN, D. ; UNAL, S. ; UZUN, O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-4cf32138379594ba56f683e7954bbbba7b76034886b1308357da13a5d638beaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bacteria</topic><topic>Bacterial diseases</topic><topic>Bacterial sepsis</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood pressure</topic><topic>Developing Countries</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gram negative bacteria</topic><topic>Gram-positive bacteria</topic><topic>Health outcomes</topic><topic>Hospitals</topic><topic>Hospitals, University - statistics & numerical data</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Intensive care units</topic><topic>Kidney Diseases - complications</topic><topic>LDCs</topic><topic>Male</topic><topic>Medical Records</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Microbiology</topic><topic>Microorganisms</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Pathogens</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Respiration, Artificial</topic><topic>Retrospective Studies</topic><topic>Sepsis</topic><topic>Sepsis - mortality</topic><topic>Sepsis - pathology</topic><topic>Sepsis - therapy</topic><topic>Septic shock</topic><topic>Survival Analysis</topic><topic>Turkey - epidemiology</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TANRIOVER, M. D.</creatorcontrib><creatorcontrib>GUVEN, G. S.</creatorcontrib><creatorcontrib>SEN, D.</creatorcontrib><creatorcontrib>UNAL, S.</creatorcontrib><creatorcontrib>UZUN, O.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epidemiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TANRIOVER, M. D.</au><au>GUVEN, G. S.</au><au>SEN, D.</au><au>UNAL, S.</au><au>UZUN, O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology and outcome of sepsis in a tertiary-care hospital in a developing country</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>134</volume><issue>2</issue><spage>315</spage><epage>322</epage><pages>315-322</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><coden>EPINEU</coden><abstract>Sepsis continues to have a substantial mortality and morbidity despite advances in the diagnosis and management of this condition. We retrospectively analysed hospital charts of patients diagnosed to have sepsis between January 2002 and June 2003. Demographic characteristics of patients, microbiological findings and predictors of survival were evaluated. Sixty-nine sepsis episodes that occurred in 63 patients were analysed. The most common underlying diseases were hypertension, malignancies and diabetes mellitus. Renal insufficiency, respiratory distress and disseminated intravascular coagulation developed in 52·2, 30·4 and 30·4% of the episodes respectively; 47·7% of the blood cultures yielded an organism. Gram-negative bacteria were the predominant microorganisms (65·9%). Fifty-five patients (87·3%) died. Mechanical ventilation and underlying renal disease were significant determinants of mortality. In conclusion, Gram-negative bacteria remain the major pathogens in sepsis. The mortality remains very high, and a change in the clinical approach to the septic patient should be employed to improve the outcome.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>16490136</pmid><doi>10.1017/S0950268805004978</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-2688 |
| ispartof | Epidemiology and infection, 2006-04, Vol.134 (2), p.315-322 |
| issn | 0950-2688 1469-4409 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2870389 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central |
| subjects | Adult Aged Bacteria Bacterial diseases Bacterial sepsis Biological and medical sciences Blood Blood pressure Developing Countries Epidemiology Female Fundamental and applied biological sciences. Psychology Gram negative bacteria Gram-positive bacteria Health outcomes Hospitals Hospitals, University - statistics & numerical data Human bacterial diseases Humans Incidence Infections Infectious diseases Intensive care units Kidney Diseases - complications LDCs Male Medical Records Medical sciences Medicine Microbiology Microorganisms Middle Aged Mortality Pathogens Patients Prognosis Respiration, Artificial Retrospective Studies Sepsis Sepsis - mortality Sepsis - pathology Sepsis - therapy Septic shock Survival Analysis Turkey - epidemiology Ventilators |
| title | Epidemiology and outcome of sepsis in a tertiary-care hospital in a developing country |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T15%3A25%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Epidemiology%20and%20outcome%20of%20sepsis%20in%20a%20tertiary-care%20hospital%20in%20a%20developing%20country&rft.jtitle=Epidemiology%20and%20infection&rft.au=TANRIOVER,%20M.%20D.&rft.date=2006-04-01&rft.volume=134&rft.issue=2&rft.spage=315&rft.epage=322&rft.pages=315-322&rft.issn=0950-2688&rft.eissn=1469-4409&rft.coden=EPINEU&rft_id=info:doi/10.1017/S0950268805004978&rft_dat=%3Cjstor_pubme%3E3865635%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=205481244&rft_id=info:pmid/16490136&rft_cupid=10_1017_S0950268805004978&rft_jstor_id=3865635&rfr_iscdi=true |