Invasive Streptococcus pneumoniae isolates from Argentinian children: serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity
PspA is an antigenically variable virulence factor of Streptococcus pneumoniae that inhibits complement deposition and is a potential candidate for human vaccines. Of 64 published strains 96% are in PspA families 1 and 2; optimal protection is family-specific. Effective development of a PspA-contain...
Gespeichert in:
| Veröffentlicht in: | Epidemiology and infection 2004-04, Vol.132 (2), p.177-184 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 184 |
|---|---|
| container_issue | 2 |
| container_start_page | 177 |
| container_title | Epidemiology and infection |
| container_volume | 132 |
| creator | MOLLERACH, M. REGUEIRA, M. BONOFIGLIO, L. CALLEJO, R. PACE, J. DI FABIO, J. L. HOLLINGSHEAD, S. BRILES, D. |
| description | PspA is an antigenically variable virulence factor of Streptococcus pneumoniae that inhibits complement deposition and is a potential candidate for human vaccines. Of 64 published strains 96% are in PspA families 1 and 2; optimal protection is family-specific. Effective development of a PspA-containing vaccine requires more information about the PspA family of strains in parts of the world where the vaccine is most needed. In these studies we observed that of 149 isolates (of 19 capsular types) from Argentina, 54·4% were family 1, 41·6% were family 2 and 4·0% expressed both family 1 and family 2 PspAs. Box typing revealed the Argentinian strains to be from at least 10 clonally related groups. |
| doi_str_mv | 10.1017/S0950268803001626 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2870092</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0950268803001626</cupid><jstor_id>3865808</jstor_id><sourcerecordid>3865808</sourcerecordid><originalsourceid>FETCH-LOGICAL-c611t-fc0971df5e365d890ef2309e58acd3986842a52c3eb8b1619ce375c9b882f0583</originalsourceid><addsrcrecordid>eNqFkl-L1DAUxYso7rj6AQSRICgKVpN2kiY-CMPizi6s_1h98SVk0pvdjG1Sk3Zwvokf19Qps6siPuXh_O7hnpObZfcJfkEwqV6eY0FxwTjHJcaEFexGNiNzJvL5HIub2WyU81E_yO7EuMYYi4JXt7MDQjEjc0Fm2Y9Tt1HRbgCd9wG63muv9RBR52BovbMKkI2-UT1EZIJv0SJcgOttUhzSl7apA7hXKELw_baD-BwZ1drGJtybyWW0VA2KQzBKA-oSCtahBXr6IXaLZ0i5GiVT6K1GdVolRNtv72a3jGoi3Jvew-zz8ZtPRyf52fvl6dHiLNeMkD43GouK1IZCyWjNBQZTlFgA5UrXpeCMzwtFC13Ciq8II0JDWVEtVpwXBlNeHmavd77dsGqh1ilcUI3sgm1V2EqvrPxdcfZSXviNTE2OfSaDJ5NB8N8GiL1sbdTQNMqBH6KsCMeYU_pfkFSiEvgX-OgPcO2H4FILskg65iUZIbKDdPAxBjD7lQmW43XIv64jzTy8nvVqYjqHBDyeABXTl5mgnLbxGseoSEsm7sGOW8feh71eckY5HjvNd7KNPXzfyyp8laxK9Uu2_CjffRFvl8e4kieJL6csql0FW1_AVeJ_p_kJR8rsyg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>205508315</pqid></control><display><type>article</type><title>Invasive Streptococcus pneumoniae isolates from Argentinian children: serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>PubMed Central</source><creator>MOLLERACH, M. ; REGUEIRA, M. ; BONOFIGLIO, L. ; CALLEJO, R. ; PACE, J. ; DI FABIO, J. L. ; HOLLINGSHEAD, S. ; BRILES, D.</creator><creatorcontrib>MOLLERACH, M. ; REGUEIRA, M. ; BONOFIGLIO, L. ; CALLEJO, R. ; PACE, J. ; DI FABIO, J. L. ; HOLLINGSHEAD, S. ; BRILES, D. ; Streptococcus pneumoniae Working Group</creatorcontrib><description>PspA is an antigenically variable virulence factor of Streptococcus pneumoniae that inhibits complement deposition and is a potential candidate for human vaccines. Of 64 published strains 96% are in PspA families 1 and 2; optimal protection is family-specific. Effective development of a PspA-containing vaccine requires more information about the PspA family of strains in parts of the world where the vaccine is most needed. In these studies we observed that of 149 isolates (of 19 capsular types) from Argentina, 54·4% were family 1, 41·6% were family 2 and 4·0% expressed both family 1 and family 2 PspAs. Box typing revealed the Argentinian strains to be from at least 10 clonally related groups.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268803001626</identifier><identifier>PMID: 15061491</identifier><identifier>CODEN: EPINEU</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Antibodies ; Bacterial Proteins - genetics ; Bacteriology ; Biological and medical sciences ; Child ; Child, Preschool ; Children ; DNA ; Fundamental and applied biological sciences. Psychology ; Genetic diversity ; Genetic Variation ; Humans ; Infant ; Infant, Newborn ; Infections ; Membrane proteins ; Microbiology ; Miscellaneous ; Penicillin ; Pneumonia ; Polymerase chain reaction ; Proteins ; Serotyping ; Streptococcus infections ; Streptococcus pneumoniae ; Streptococcus pneumoniae - classification ; Streptococcus pneumoniae - genetics ; Streptococcus pneumoniae - immunology ; Vaccination ; Vaccines ; Virulence ; Working groups</subject><ispartof>Epidemiology and infection, 2004-04, Vol.132 (2), p.177-184</ispartof><rights>2003 Cambridge University Press</rights><rights>Copyright 2004 Cambridge University Press</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-fc0971df5e365d890ef2309e58acd3986842a52c3eb8b1619ce375c9b882f0583</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3865808$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3865808$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15659979$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15061491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MOLLERACH, M.</creatorcontrib><creatorcontrib>REGUEIRA, M.</creatorcontrib><creatorcontrib>BONOFIGLIO, L.</creatorcontrib><creatorcontrib>CALLEJO, R.</creatorcontrib><creatorcontrib>PACE, J.</creatorcontrib><creatorcontrib>DI FABIO, J. L.</creatorcontrib><creatorcontrib>HOLLINGSHEAD, S.</creatorcontrib><creatorcontrib>BRILES, D.</creatorcontrib><creatorcontrib>Streptococcus pneumoniae Working Group</creatorcontrib><title>Invasive Streptococcus pneumoniae isolates from Argentinian children: serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>PspA is an antigenically variable virulence factor of Streptococcus pneumoniae that inhibits complement deposition and is a potential candidate for human vaccines. Of 64 published strains 96% are in PspA families 1 and 2; optimal protection is family-specific. Effective development of a PspA-containing vaccine requires more information about the PspA family of strains in parts of the world where the vaccine is most needed. In these studies we observed that of 149 isolates (of 19 capsular types) from Argentina, 54·4% were family 1, 41·6% were family 2 and 4·0% expressed both family 1 and family 2 PspAs. Box typing revealed the Argentinian strains to be from at least 10 clonally related groups.</description><subject>Antibodies</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>DNA</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic diversity</subject><subject>Genetic Variation</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Membrane proteins</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Penicillin</subject><subject>Pneumonia</subject><subject>Polymerase chain reaction</subject><subject>Proteins</subject><subject>Serotyping</subject><subject>Streptococcus infections</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - classification</subject><subject>Streptococcus pneumoniae - genetics</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Virulence</subject><subject>Working groups</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkl-L1DAUxYso7rj6AQSRICgKVpN2kiY-CMPizi6s_1h98SVk0pvdjG1Sk3Zwvokf19Qps6siPuXh_O7hnpObZfcJfkEwqV6eY0FxwTjHJcaEFexGNiNzJvL5HIub2WyU81E_yO7EuMYYi4JXt7MDQjEjc0Fm2Y9Tt1HRbgCd9wG63muv9RBR52BovbMKkI2-UT1EZIJv0SJcgOttUhzSl7apA7hXKELw_baD-BwZ1drGJtybyWW0VA2KQzBKA-oSCtahBXr6IXaLZ0i5GiVT6K1GdVolRNtv72a3jGoi3Jvew-zz8ZtPRyf52fvl6dHiLNeMkD43GouK1IZCyWjNBQZTlFgA5UrXpeCMzwtFC13Ciq8II0JDWVEtVpwXBlNeHmavd77dsGqh1ilcUI3sgm1V2EqvrPxdcfZSXviNTE2OfSaDJ5NB8N8GiL1sbdTQNMqBH6KsCMeYU_pfkFSiEvgX-OgPcO2H4FILskg65iUZIbKDdPAxBjD7lQmW43XIv64jzTy8nvVqYjqHBDyeABXTl5mgnLbxGseoSEsm7sGOW8feh71eckY5HjvNd7KNPXzfyyp8laxK9Uu2_CjffRFvl8e4kieJL6csql0FW1_AVeJ_p_kJR8rsyg</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>MOLLERACH, M.</creator><creator>REGUEIRA, M.</creator><creator>BONOFIGLIO, L.</creator><creator>CALLEJO, R.</creator><creator>PACE, J.</creator><creator>DI FABIO, J. L.</creator><creator>HOLLINGSHEAD, S.</creator><creator>BRILES, D.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040401</creationdate><title>Invasive Streptococcus pneumoniae isolates from Argentinian children: serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity</title><author>MOLLERACH, M. ; REGUEIRA, M. ; BONOFIGLIO, L. ; CALLEJO, R. ; PACE, J. ; DI FABIO, J. L. ; HOLLINGSHEAD, S. ; BRILES, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-fc0971df5e365d890ef2309e58acd3986842a52c3eb8b1619ce375c9b882f0583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antibodies</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>DNA</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic diversity</topic><topic>Genetic Variation</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Membrane proteins</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Penicillin</topic><topic>Pneumonia</topic><topic>Polymerase chain reaction</topic><topic>Proteins</topic><topic>Serotyping</topic><topic>Streptococcus infections</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - classification</topic><topic>Streptococcus pneumoniae - genetics</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Virulence</topic><topic>Working groups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOLLERACH, M.</creatorcontrib><creatorcontrib>REGUEIRA, M.</creatorcontrib><creatorcontrib>BONOFIGLIO, L.</creatorcontrib><creatorcontrib>CALLEJO, R.</creatorcontrib><creatorcontrib>PACE, J.</creatorcontrib><creatorcontrib>DI FABIO, J. L.</creatorcontrib><creatorcontrib>HOLLINGSHEAD, S.</creatorcontrib><creatorcontrib>BRILES, D.</creatorcontrib><creatorcontrib>Streptococcus pneumoniae Working Group</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epidemiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOLLERACH, M.</au><au>REGUEIRA, M.</au><au>BONOFIGLIO, L.</au><au>CALLEJO, R.</au><au>PACE, J.</au><au>DI FABIO, J. L.</au><au>HOLLINGSHEAD, S.</au><au>BRILES, D.</au><aucorp>Streptococcus pneumoniae Working Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Invasive Streptococcus pneumoniae isolates from Argentinian children: serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>132</volume><issue>2</issue><spage>177</spage><epage>184</epage><pages>177-184</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><coden>EPINEU</coden><abstract>PspA is an antigenically variable virulence factor of Streptococcus pneumoniae that inhibits complement deposition and is a potential candidate for human vaccines. Of 64 published strains 96% are in PspA families 1 and 2; optimal protection is family-specific. Effective development of a PspA-containing vaccine requires more information about the PspA family of strains in parts of the world where the vaccine is most needed. In these studies we observed that of 149 isolates (of 19 capsular types) from Argentina, 54·4% were family 1, 41·6% were family 2 and 4·0% expressed both family 1 and family 2 PspAs. Box typing revealed the Argentinian strains to be from at least 10 clonally related groups.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>15061491</pmid><doi>10.1017/S0950268803001626</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-2688 |
| ispartof | Epidemiology and infection, 2004-04, Vol.132 (2), p.177-184 |
| issn | 0950-2688 1469-4409 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2870092 |
| source | Jstor Complete Legacy; MEDLINE; PubMed Central |
| subjects | Antibodies Bacterial Proteins - genetics Bacteriology Biological and medical sciences Child Child, Preschool Children DNA Fundamental and applied biological sciences. Psychology Genetic diversity Genetic Variation Humans Infant Infant, Newborn Infections Membrane proteins Microbiology Miscellaneous Penicillin Pneumonia Polymerase chain reaction Proteins Serotyping Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - genetics Streptococcus pneumoniae - immunology Vaccination Vaccines Virulence Working groups |
| title | Invasive Streptococcus pneumoniae isolates from Argentinian children: serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T06%3A10%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Invasive%20Streptococcus%20pneumoniae%20isolates%20from%20Argentinian%20children:%20serotypes,%20families%20of%20pneumococcal%20surface%20protein%20A%20(PspA)%20and%20genetic%20diversity&rft.jtitle=Epidemiology%20and%20infection&rft.au=MOLLERACH,%20M.&rft.aucorp=Streptococcus%20pneumoniae%20Working%20Group&rft.date=2004-04-01&rft.volume=132&rft.issue=2&rft.spage=177&rft.epage=184&rft.pages=177-184&rft.issn=0950-2688&rft.eissn=1469-4409&rft.coden=EPINEU&rft_id=info:doi/10.1017/S0950268803001626&rft_dat=%3Cjstor_pubme%3E3865808%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=205508315&rft_id=info:pmid/15061491&rft_cupid=10_1017_S0950268803001626&rft_jstor_id=3865808&rfr_iscdi=true |