Molecular epidemiology of group B streptococci in Ireland: associations between serotype, invasive status and presence of genes encoding putative virulence factors
Group B streptococcal isolates (n=159) from the three Dublin maternity hospitals, were serotyped and analysed for the bac, bca, hylB, pepB, and rib genes. The serotype distribution of the isolates was Ia, 19·5%; Ib, 18·9%; II, 10·7%; III, 29·5%; IV, 1·9%; V, 15·1%; non-typeable, 4·4%. There was a st...
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| Veröffentlicht in: | Epidemiology and infection 2003-10, Vol.131 (2), p.823-833 |
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| creator | DORE, N. BENNETT, D. KALISZER, M. CAFFERKEY, M. SMYTH, C. J. |
| description | Group B streptococcal isolates (n=159) from the three Dublin maternity hospitals, were serotyped and analysed for the bac, bca, hylB, pepB, and rib genes. The serotype distribution of the isolates was Ia, 19·5%; Ib, 18·9%; II, 10·7%; III, 29·5%; IV, 1·9%; V, 15·1%; non-typeable, 4·4%. There was a statistically significant association between the serotype and invasive status (carriage or infection) of isolates (P |
| doi_str_mv | 10.1017/S0950268803008847 |
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J.</creator><creatorcontrib>DORE, N. ; BENNETT, D. ; KALISZER, M. ; CAFFERKEY, M. ; SMYTH, C. J.</creatorcontrib><description>Group B streptococcal isolates (n=159) from the three Dublin maternity hospitals, were serotyped and analysed for the bac, bca, hylB, pepB, and rib genes. The serotype distribution of the isolates was Ia, 19·5%; Ib, 18·9%; II, 10·7%; III, 29·5%; IV, 1·9%; V, 15·1%; non-typeable, 4·4%. There was a statistically significant association between the serotype and invasive status (carriage or infection) of isolates (P<0·005), but no significant association between serotype and degree of invasiveness was demonstrated. The presence or absence of each analysed gene was not associated with the invasive status of isolates. Statistically significant associations were revealed between bca and hylB (IS1548) (P=0·0004) and between bac and bca (P=0·0l4). The bac, bca, hylB (IS1548) and rib genes and the numbers of tandem repeats in the bca gene showed significant associations with serotype. Almost 50% of serotype III isolates possessed at least one of the bac and bca genes and 55–65% of strains of serotypes Ia, Ib and II possessed the rib gene. Most serotype III isolates had IS1548 in their hylB genes. Serotype Ib was the only serotype in which more than half of the strains contained more tandem repeats in the bca gene than the overall mean for the GBS population studied of 7·4 repeats. These findings indicate that some previously reported associations between putative virulence factors and GBS disease require further study and clarification.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268803008847</identifier><identifier>PMID: 14596522</identifier><identifier>CODEN: EPINEU</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Asymptomatic ; Bacteriology ; Biological and medical sciences ; Breastfeeding & lactation ; Chi-Square Distribution ; DNA ; Enzymes ; Epidemiology ; Fundamental and applied biological sciences. Psychology ; Genes ; Genotype ; Hospitals ; Humans ; Infections ; Ireland - epidemiology ; Laboratories ; Microbiology ; Miscellaneous ; Molecular Epidemiology ; Polymerase Chain Reaction ; Polysaccharides ; Proteins ; Sequence Analysis, DNA ; Serotyping ; Statistical significance ; Statistics, Nonparametric ; Streptococcus ; Streptococcus agalactiae ; Streptococcus agalactiae - classification ; Streptococcus agalactiae - genetics ; Streptococcus agalactiae - pathogenicity ; Tandem repeat sequences ; Virulence ; Virulence - genetics ; Virulence factors</subject><ispartof>Epidemiology and infection, 2003-10, Vol.131 (2), p.823-833</ispartof><rights>2003 Cambridge University Press</rights><rights>Copyright 2003 Cambridge University Press</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-ff7526cca5ab8e10c977bf2d7d64387e24ddd2dab226e1e4665920b237a042b23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3865293$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3865293$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15189457$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14596522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DORE, N.</creatorcontrib><creatorcontrib>BENNETT, D.</creatorcontrib><creatorcontrib>KALISZER, M.</creatorcontrib><creatorcontrib>CAFFERKEY, M.</creatorcontrib><creatorcontrib>SMYTH, C. J.</creatorcontrib><title>Molecular epidemiology of group B streptococci in Ireland: associations between serotype, invasive status and presence of genes encoding putative virulence factors</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>Group B streptococcal isolates (n=159) from the three Dublin maternity hospitals, were serotyped and analysed for the bac, bca, hylB, pepB, and rib genes. The serotype distribution of the isolates was Ia, 19·5%; Ib, 18·9%; II, 10·7%; III, 29·5%; IV, 1·9%; V, 15·1%; non-typeable, 4·4%. There was a statistically significant association between the serotype and invasive status (carriage or infection) of isolates (P<0·005), but no significant association between serotype and degree of invasiveness was demonstrated. The presence or absence of each analysed gene was not associated with the invasive status of isolates. Statistically significant associations were revealed between bca and hylB (IS1548) (P=0·0004) and between bac and bca (P=0·0l4). The bac, bca, hylB (IS1548) and rib genes and the numbers of tandem repeats in the bca gene showed significant associations with serotype. Almost 50% of serotype III isolates possessed at least one of the bac and bca genes and 55–65% of strains of serotypes Ia, Ib and II possessed the rib gene. Most serotype III isolates had IS1548 in their hylB genes. Serotype Ib was the only serotype in which more than half of the strains contained more tandem repeats in the bca gene than the overall mean for the GBS population studied of 7·4 repeats. These findings indicate that some previously reported associations between putative virulence factors and GBS disease require further study and clarification.</description><subject>Asymptomatic</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Breastfeeding & lactation</subject><subject>Chi-Square Distribution</subject><subject>DNA</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes</subject><subject>Genotype</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infections</subject><subject>Ireland - epidemiology</subject><subject>Laboratories</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Molecular Epidemiology</subject><subject>Polymerase Chain Reaction</subject><subject>Polysaccharides</subject><subject>Proteins</subject><subject>Sequence Analysis, DNA</subject><subject>Serotyping</subject><subject>Statistical significance</subject><subject>Statistics, Nonparametric</subject><subject>Streptococcus</subject><subject>Streptococcus agalactiae</subject><subject>Streptococcus agalactiae - classification</subject><subject>Streptococcus agalactiae - genetics</subject><subject>Streptococcus agalactiae - pathogenicity</subject><subject>Tandem repeat sequences</subject><subject>Virulence</subject><subject>Virulence - genetics</subject><subject>Virulence factors</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkl2L1DAUhoso7rj6AwSRIOiV1SRtksYLQRddV9Yv1BtvQpqejhk7SU3a0fk9_lHTnTLjB-LVIbzPeTnvycmymwQ_IJiIh--xZJjyqsIFxlVVikvZgpRc5mWJ5eVsMcn5pB9l12JcYYwlrcTV7IiUTHJG6SL78cp3YMZOBwS9bWBtfeeXW-RbtAx-7NFTFIcA_eCNN8Yi69BZgE675hHSMXpj9WC9i6iG4RuAQxGCH7Y93E_oRke7gWSghzGi1IP6ABGcgQt_cBBRevnGuiXqx4RN-MaGsbuAWm0GH-L17Eqruwg35nqcfXz-7MPJi_z8zenZyZPz3LCyGPK2FYxyYzTTdQUEGylE3dJGNLwsKgG0bJqGNrqmlAOBknMmKa5pITQuaarH2eOdbz_Wa2gMuCHoTvXBrnXYKq-t-l1x9rNa-o1KS8WYsmRwbzYI_usIcVBrGw10aV3gx6gEKQqGRfFfkEhKOOYTeOcPcOXH4NIWFMWMESE5TxDZQSb4GAO0-5EJVtOhqL8OJfXc_jXroWO-jATcnQEdje7aoJ2x8cAxUsmSTUa3dtwqpr_a60WVXOQUIN_JNg7wfS_r8EVxUQim-Ok79Zal6V5Wn9TrxBdzFr2ug22WcEj87zQ_AWZ68es</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>DORE, N.</creator><creator>BENNETT, D.</creator><creator>KALISZER, M.</creator><creator>CAFFERKEY, M.</creator><creator>SMYTH, C. 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J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-ff7526cca5ab8e10c977bf2d7d64387e24ddd2dab226e1e4665920b237a042b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Asymptomatic</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Breastfeeding & lactation</topic><topic>Chi-Square Distribution</topic><topic>DNA</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes</topic><topic>Genotype</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infections</topic><topic>Ireland - epidemiology</topic><topic>Laboratories</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Molecular Epidemiology</topic><topic>Polymerase Chain Reaction</topic><topic>Polysaccharides</topic><topic>Proteins</topic><topic>Sequence Analysis, DNA</topic><topic>Serotyping</topic><topic>Statistical significance</topic><topic>Statistics, Nonparametric</topic><topic>Streptococcus</topic><topic>Streptococcus agalactiae</topic><topic>Streptococcus agalactiae - classification</topic><topic>Streptococcus agalactiae - genetics</topic><topic>Streptococcus agalactiae - pathogenicity</topic><topic>Tandem repeat sequences</topic><topic>Virulence</topic><topic>Virulence - genetics</topic><topic>Virulence factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DORE, N.</creatorcontrib><creatorcontrib>BENNETT, D.</creatorcontrib><creatorcontrib>KALISZER, M.</creatorcontrib><creatorcontrib>CAFFERKEY, M.</creatorcontrib><creatorcontrib>SMYTH, C. 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J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular epidemiology of group B streptococci in Ireland: associations between serotype, invasive status and presence of genes encoding putative virulence factors</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>131</volume><issue>2</issue><spage>823</spage><epage>833</epage><pages>823-833</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><coden>EPINEU</coden><abstract>Group B streptococcal isolates (n=159) from the three Dublin maternity hospitals, were serotyped and analysed for the bac, bca, hylB, pepB, and rib genes. The serotype distribution of the isolates was Ia, 19·5%; Ib, 18·9%; II, 10·7%; III, 29·5%; IV, 1·9%; V, 15·1%; non-typeable, 4·4%. There was a statistically significant association between the serotype and invasive status (carriage or infection) of isolates (P<0·005), but no significant association between serotype and degree of invasiveness was demonstrated. The presence or absence of each analysed gene was not associated with the invasive status of isolates. Statistically significant associations were revealed between bca and hylB (IS1548) (P=0·0004) and between bac and bca (P=0·0l4). The bac, bca, hylB (IS1548) and rib genes and the numbers of tandem repeats in the bca gene showed significant associations with serotype. Almost 50% of serotype III isolates possessed at least one of the bac and bca genes and 55–65% of strains of serotypes Ia, Ib and II possessed the rib gene. Most serotype III isolates had IS1548 in their hylB genes. Serotype Ib was the only serotype in which more than half of the strains contained more tandem repeats in the bca gene than the overall mean for the GBS population studied of 7·4 repeats. These findings indicate that some previously reported associations between putative virulence factors and GBS disease require further study and clarification.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>14596522</pmid><doi>10.1017/S0950268803008847</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Epidemiology and infection, 2003-10, Vol.131 (2), p.823-833 |
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| source | MEDLINE; Jstor Complete Legacy; PubMed Central |
| subjects | Asymptomatic Bacteriology Biological and medical sciences Breastfeeding & lactation Chi-Square Distribution DNA Enzymes Epidemiology Fundamental and applied biological sciences. Psychology Genes Genotype Hospitals Humans Infections Ireland - epidemiology Laboratories Microbiology Miscellaneous Molecular Epidemiology Polymerase Chain Reaction Polysaccharides Proteins Sequence Analysis, DNA Serotyping Statistical significance Statistics, Nonparametric Streptococcus Streptococcus agalactiae Streptococcus agalactiae - classification Streptococcus agalactiae - genetics Streptococcus agalactiae - pathogenicity Tandem repeat sequences Virulence Virulence - genetics Virulence factors |
| title | Molecular epidemiology of group B streptococci in Ireland: associations between serotype, invasive status and presence of genes encoding putative virulence factors |
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