Fortification of orange juice with vitamin D₂ or vitamin D₃ is as effective as an oral supplement in maintaining vitamin D status in adults
BACKGROUND: Vitamin D has been added to calcium-fortified orange juice. It is unknown whether vitamin D is as bioavailable from orange juice as it is from supplements. OBJECTIVES: The objective was to compare the bioavailability of vitamin D₂ and vitamin D₃ from orange juice with that from vitamin D...
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| Veröffentlicht in: | The American journal of clinical nutrition 2010-06, Vol.91 (6), p.1621-1626 |
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| container_title | The American journal of clinical nutrition |
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| creator | Biancuzzo, Rachael M Young, Azzie Bibuld, Douglass Cai, Mona H Winter, Michael R Klein, Ellen K Ameri, Allen Reitz, Richard Salameh, Wael Chen, Tai C Holick, Michael F |
| description | BACKGROUND: Vitamin D has been added to calcium-fortified orange juice. It is unknown whether vitamin D is as bioavailable from orange juice as it is from supplements. OBJECTIVES: The objective was to compare the bioavailability of vitamin D₂ and vitamin D₃ from orange juice with that from vitamin D₂ and vitamin D₃ supplements. A secondary aim was to determine which form of vitamin D is more bioavailable in orange juice. DESIGN: A randomized, placebo-controlled, double-blind study was conducted in healthy adults aged 18-84 y (15-20/group) who received 1000 IU vitamin D₃, 1000 IU vitamin D₂, or placebo in orange juice or capsule for 11 wk at the end of winter. RESULTS: A total of 64% of subjects began the study deficient in vitamin D (ie, 25-hydroxyvitamin D [25(OH)D]) concentrations 0.1). Similarly, no significant difference in serum 25(OH)D₂ was observed between subjects who consumed vitamin D₂-fortified orange juice and vitamin D₂ capsules (P > 0.1). No significant overall difference in parathyroid hormone concentrations was observed between the groups (P = 0.82). CONCLUSION: Vitamin D₂ and vitamin D₃ are equally bioavailable in orange juice and capsules. |
| doi_str_mv | 10.3945/ajcn.2009.27972 |
| format | Article |
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It is unknown whether vitamin D is as bioavailable from orange juice as it is from supplements. OBJECTIVES: The objective was to compare the bioavailability of vitamin D₂ and vitamin D₃ from orange juice with that from vitamin D₂ and vitamin D₃ supplements. A secondary aim was to determine which form of vitamin D is more bioavailable in orange juice. DESIGN: A randomized, placebo-controlled, double-blind study was conducted in healthy adults aged 18-84 y (15-20/group) who received 1000 IU vitamin D₃, 1000 IU vitamin D₂, or placebo in orange juice or capsule for 11 wk at the end of winter. RESULTS: A total of 64% of subjects began the study deficient in vitamin D (ie, 25-hydroxyvitamin D [25(OH)D]) concentrations <20 ng/mL). Analysis of the area under the curve showed no significant difference in serum 25(OH)D between subjects who consumed vitamin D-fortified orange juice and those who consumed vitamin D supplements (P = 0.084). No significant difference in serum 25(OH)D₃ was observed between subjects who consumed vitamin D₃-fortified orange juice and vitamin D₃ capsules (P > 0.1). Similarly, no significant difference in serum 25(OH)D₂ was observed between subjects who consumed vitamin D₂-fortified orange juice and vitamin D₂ capsules (P > 0.1). No significant overall difference in parathyroid hormone concentrations was observed between the groups (P = 0.82). CONCLUSION: Vitamin D₂ and vitamin D₃ are equally bioavailable in orange juice and capsules.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.2009.27972</identifier><identifier>PMID: 20427729</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Clinical Nutrition</publisher><subject>adults ; Biological and medical sciences ; cholecalciferol ; ergocalciferol ; Feeding. Feeding behavior ; food fortification ; fortified foods ; Fundamental and applied biological sciences. Psychology ; nutrient availability ; nutrition assessment ; nutritional status ; oral administration ; orange juice ; Original Research Communications ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; vitamin supplements ; Vitamins, Minerals, and Phytochemicals</subject><ispartof>The American journal of clinical nutrition, 2010-06, Vol.91 (6), p.1621-1626</ispartof><rights>2015 INIST-CNRS</rights><rights>2010 American Society for Nutrition 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2362-602507b869c107c0c9ca711a2626086abc07a1a27508ab42a638041fed02d30d3</citedby><cites>FETCH-LOGICAL-c2362-602507b869c107c0c9ca711a2626086abc07a1a27508ab42a638041fed02d30d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22807177$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Biancuzzo, Rachael M</creatorcontrib><creatorcontrib>Young, Azzie</creatorcontrib><creatorcontrib>Bibuld, Douglass</creatorcontrib><creatorcontrib>Cai, Mona H</creatorcontrib><creatorcontrib>Winter, Michael R</creatorcontrib><creatorcontrib>Klein, Ellen K</creatorcontrib><creatorcontrib>Ameri, Allen</creatorcontrib><creatorcontrib>Reitz, Richard</creatorcontrib><creatorcontrib>Salameh, Wael</creatorcontrib><creatorcontrib>Chen, Tai C</creatorcontrib><creatorcontrib>Holick, Michael F</creatorcontrib><title>Fortification of orange juice with vitamin D₂ or vitamin D₃ is as effective as an oral supplement in maintaining vitamin D status in adults</title><title>The American journal of clinical nutrition</title><description>BACKGROUND: Vitamin D has been added to calcium-fortified orange juice. It is unknown whether vitamin D is as bioavailable from orange juice as it is from supplements. OBJECTIVES: The objective was to compare the bioavailability of vitamin D₂ and vitamin D₃ from orange juice with that from vitamin D₂ and vitamin D₃ supplements. A secondary aim was to determine which form of vitamin D is more bioavailable in orange juice. DESIGN: A randomized, placebo-controlled, double-blind study was conducted in healthy adults aged 18-84 y (15-20/group) who received 1000 IU vitamin D₃, 1000 IU vitamin D₂, or placebo in orange juice or capsule for 11 wk at the end of winter. RESULTS: A total of 64% of subjects began the study deficient in vitamin D (ie, 25-hydroxyvitamin D [25(OH)D]) concentrations <20 ng/mL). Analysis of the area under the curve showed no significant difference in serum 25(OH)D between subjects who consumed vitamin D-fortified orange juice and those who consumed vitamin D supplements (P = 0.084). No significant difference in serum 25(OH)D₃ was observed between subjects who consumed vitamin D₃-fortified orange juice and vitamin D₃ capsules (P > 0.1). Similarly, no significant difference in serum 25(OH)D₂ was observed between subjects who consumed vitamin D₂-fortified orange juice and vitamin D₂ capsules (P > 0.1). No significant overall difference in parathyroid hormone concentrations was observed between the groups (P = 0.82). CONCLUSION: Vitamin D₂ and vitamin D₃ are equally bioavailable in orange juice and capsules.</description><subject>adults</subject><subject>Biological and medical sciences</subject><subject>cholecalciferol</subject><subject>ergocalciferol</subject><subject>Feeding. Feeding behavior</subject><subject>food fortification</subject><subject>fortified foods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>nutrient availability</subject><subject>nutrition assessment</subject><subject>nutritional status</subject><subject>oral administration</subject><subject>orange juice</subject><subject>Original Research Communications</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>vitamin supplements</subject><subject>Vitamins, Minerals, and Phytochemicals</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNpVUU1v1DAQtRCIbgtnjvjCMdvxOLGTCxIqtCBV6gF6tmYdZ-tV4qxiZxHX8gP4j_wSHLYq9GBZT-9jRvMYeyNgLZuyOqedDWsEaNaoG43P2Eo0si4kgn7OVgCARSNUdcJOY9wBCCxr9ZKdIJSoNTYr9utynJLvvKXkx8DHjo8Tha3ju9lbx7_7dMcPPtHgA__4-_4-0__jn9xHTpG7rnM2-YNbAIUlpOdx3u97N7iQeFYP5EPKz4ftvwQeE6U5Ljy1c5_iK_aioz661w__Gbu9_PTt4nNxfXP15eLDdWFRKiwUYAV6U6vGCtAWbGNJC0GoUEGtaGNBU4a6gpo2JZKSNZSicy1gK6GVZ-z9MXc_bwbX2rxkXtnsJz_Q9MOM5M1TJvg7sx0PBvPMSkAOOD8G2GmMcXLdo1eAWboxSzdm6cb87SY73j2MpGip7_KdrY-PNsQatNA6694edR2NhrZT1tx-RRASRF2WWKH8Ax3Dmys</recordid><startdate>201006</startdate><enddate>201006</enddate><creator>Biancuzzo, Rachael M</creator><creator>Young, Azzie</creator><creator>Bibuld, Douglass</creator><creator>Cai, Mona H</creator><creator>Winter, Michael R</creator><creator>Klein, Ellen K</creator><creator>Ameri, Allen</creator><creator>Reitz, Richard</creator><creator>Salameh, Wael</creator><creator>Chen, Tai C</creator><creator>Holick, Michael F</creator><general>American Society for Clinical Nutrition</general><general>American Society for Nutrition</general><scope>FBQ</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>201006</creationdate><title>Fortification of orange juice with vitamin D₂ or vitamin D₃ is as effective as an oral supplement in maintaining vitamin D status in adults</title><author>Biancuzzo, Rachael M ; Young, Azzie ; Bibuld, Douglass ; Cai, Mona H ; Winter, Michael R ; Klein, Ellen K ; Ameri, Allen ; Reitz, Richard ; Salameh, Wael ; Chen, Tai C ; Holick, Michael F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2362-602507b869c107c0c9ca711a2626086abc07a1a27508ab42a638041fed02d30d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>adults</topic><topic>Biological and medical sciences</topic><topic>cholecalciferol</topic><topic>ergocalciferol</topic><topic>Feeding. Feeding behavior</topic><topic>food fortification</topic><topic>fortified foods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>nutrient availability</topic><topic>nutrition assessment</topic><topic>nutritional status</topic><topic>oral administration</topic><topic>orange juice</topic><topic>Original Research Communications</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>vitamin supplements</topic><topic>Vitamins, Minerals, and Phytochemicals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biancuzzo, Rachael M</creatorcontrib><creatorcontrib>Young, Azzie</creatorcontrib><creatorcontrib>Bibuld, Douglass</creatorcontrib><creatorcontrib>Cai, Mona H</creatorcontrib><creatorcontrib>Winter, Michael R</creatorcontrib><creatorcontrib>Klein, Ellen K</creatorcontrib><creatorcontrib>Ameri, Allen</creatorcontrib><creatorcontrib>Reitz, Richard</creatorcontrib><creatorcontrib>Salameh, Wael</creatorcontrib><creatorcontrib>Chen, Tai C</creatorcontrib><creatorcontrib>Holick, Michael F</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biancuzzo, Rachael M</au><au>Young, Azzie</au><au>Bibuld, Douglass</au><au>Cai, Mona H</au><au>Winter, Michael R</au><au>Klein, Ellen K</au><au>Ameri, Allen</au><au>Reitz, Richard</au><au>Salameh, Wael</au><au>Chen, Tai C</au><au>Holick, Michael F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fortification of orange juice with vitamin D₂ or vitamin D₃ is as effective as an oral supplement in maintaining vitamin D status in adults</atitle><jtitle>The American journal of clinical nutrition</jtitle><date>2010-06</date><risdate>2010</risdate><volume>91</volume><issue>6</issue><spage>1621</spage><epage>1626</epage><pages>1621-1626</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>BACKGROUND: Vitamin D has been added to calcium-fortified orange juice. It is unknown whether vitamin D is as bioavailable from orange juice as it is from supplements. OBJECTIVES: The objective was to compare the bioavailability of vitamin D₂ and vitamin D₃ from orange juice with that from vitamin D₂ and vitamin D₃ supplements. A secondary aim was to determine which form of vitamin D is more bioavailable in orange juice. DESIGN: A randomized, placebo-controlled, double-blind study was conducted in healthy adults aged 18-84 y (15-20/group) who received 1000 IU vitamin D₃, 1000 IU vitamin D₂, or placebo in orange juice or capsule for 11 wk at the end of winter. RESULTS: A total of 64% of subjects began the study deficient in vitamin D (ie, 25-hydroxyvitamin D [25(OH)D]) concentrations <20 ng/mL). Analysis of the area under the curve showed no significant difference in serum 25(OH)D between subjects who consumed vitamin D-fortified orange juice and those who consumed vitamin D supplements (P = 0.084). No significant difference in serum 25(OH)D₃ was observed between subjects who consumed vitamin D₃-fortified orange juice and vitamin D₃ capsules (P > 0.1). Similarly, no significant difference in serum 25(OH)D₂ was observed between subjects who consumed vitamin D₂-fortified orange juice and vitamin D₂ capsules (P > 0.1). No significant overall difference in parathyroid hormone concentrations was observed between the groups (P = 0.82). CONCLUSION: Vitamin D₂ and vitamin D₃ are equally bioavailable in orange juice and capsules.</abstract><cop>Bethesda, MD</cop><pub>American Society for Clinical Nutrition</pub><pmid>20427729</pmid><doi>10.3945/ajcn.2009.27972</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The American journal of clinical nutrition, 2010-06, Vol.91 (6), p.1621-1626 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | adults Biological and medical sciences cholecalciferol ergocalciferol Feeding. Feeding behavior food fortification fortified foods Fundamental and applied biological sciences. Psychology nutrient availability nutrition assessment nutritional status oral administration orange juice Original Research Communications Vertebrates: anatomy and physiology, studies on body, several organs or systems vitamin supplements Vitamins, Minerals, and Phytochemicals |
| title | Fortification of orange juice with vitamin D₂ or vitamin D₃ is as effective as an oral supplement in maintaining vitamin D status in adults |
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