Cost-Effectiveness of Strategies to Improve HIV Testing and Receipt of Results: Economic Analysis of a Randomized Controlled Trial

Background The CDC recommends routine voluntary HIV testing of all patients 13-64 years of age. Despite this recommendation, HIV testing rates are low even among those at identifiable risk, and many patients do not return to receive their results. Objective To examine the costs and benefits of strat...

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Veröffentlicht in:Journal of general internal medicine : JGIM 2010-06, Vol.25 (6), p.556-563
Hauptverfasser: Sanders, Gillian D., Anaya, Henry D., Asch, Steven, Hoang, Tuyen, Golden, Joya F., Bayoumi, Ahmed M., Owens, Douglas K.
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container_end_page 563
container_issue 6
container_start_page 556
container_title Journal of general internal medicine : JGIM
container_volume 25
creator Sanders, Gillian D.
Anaya, Henry D.
Asch, Steven
Hoang, Tuyen
Golden, Joya F.
Bayoumi, Ahmed M.
Owens, Douglas K.
description Background The CDC recommends routine voluntary HIV testing of all patients 13-64 years of age. Despite this recommendation, HIV testing rates are low even among those at identifiable risk, and many patients do not return to receive their results. Objective To examine the costs and benefits of strategies to improve HIV testing and receipt of results. Design Cost-effectiveness analysis based on a Markov model. Acceptance of testing, return rates, and related costs were derived from a randomized trial of 251 patients; long-term costs and health outcomes were derived from the literature. Setting/target population Primary-care patients with unknown HIV status. Interventions Comparison of three intervention models for HIV counseling and testing: Model A = traditional HIV counseling and testing; Model B = nurse-initiated routine screening with traditional HIV testing and counseling; Model C = nurse-initiated routine screening with rapid HIV testing and streamlined counseling. Main measures Life-years, quality-adjusted life-years (QALYs), costs and incremental cost-effectiveness. Key results Without consideration of the benefit from reduced HIV transmission, Model A resulted in per-patient lifetime discounted costs of $48,650 and benefits of 16.271 QALYs. Model B increased lifetime costs by $53 and benefits by 0.0013 QALYs (corresponding to 0.48 quality-adjusted life days). Model C cost $66 more than Model A with an increase of 0.0018 QALYs (0.66 quality-adjusted life days) and an incremental cost-effectiveness of $36,390/QALY. When we included the benefit from reduced HIV transmission, Model C cost $10,660/QALY relative to Model A. The cost-effectiveness of Model C was robust in sensitivity analyses. Conclusions In a primary-care population, nurse-initiated routine screening with rapid HIV testing and streamlined counseling increased rates of testing and receipt of test results and was cost-effective compared with traditional HIV testing strategies.
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Despite this recommendation, HIV testing rates are low even among those at identifiable risk, and many patients do not return to receive their results. Objective To examine the costs and benefits of strategies to improve HIV testing and receipt of results. Design Cost-effectiveness analysis based on a Markov model. Acceptance of testing, return rates, and related costs were derived from a randomized trial of 251 patients; long-term costs and health outcomes were derived from the literature. Setting/target population Primary-care patients with unknown HIV status. Interventions Comparison of three intervention models for HIV counseling and testing: Model A = traditional HIV counseling and testing; Model B = nurse-initiated routine screening with traditional HIV testing and counseling; Model C = nurse-initiated routine screening with rapid HIV testing and streamlined counseling. Main measures Life-years, quality-adjusted life-years (QALYs), costs and incremental cost-effectiveness. Key results Without consideration of the benefit from reduced HIV transmission, Model A resulted in per-patient lifetime discounted costs of $48,650 and benefits of 16.271 QALYs. Model B increased lifetime costs by $53 and benefits by 0.0013 QALYs (corresponding to 0.48 quality-adjusted life days). Model C cost $66 more than Model A with an increase of 0.0018 QALYs (0.66 quality-adjusted life days) and an incremental cost-effectiveness of $36,390/QALY. When we included the benefit from reduced HIV transmission, Model C cost $10,660/QALY relative to Model A. The cost-effectiveness of Model C was robust in sensitivity analyses. Conclusions In a primary-care population, nurse-initiated routine screening with rapid HIV testing and streamlined counseling increased rates of testing and receipt of test results and was cost-effective compared with traditional HIV testing strategies.</description><identifier>ISSN: 0884-8734</identifier><identifier>EISSN: 1525-1497</identifier><identifier>DOI: 10.1007/s11606-010-1265-5</identifier><identifier>PMID: 20204538</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adult ; Antiretroviral drugs ; Biological and medical sciences ; Cost control ; Cost-Benefit Analysis ; Economic analysis ; General aspects ; HIV ; HIV Infections - diagnosis ; HIV Infections - economics ; HIV Infections - therapy ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Internal Medicine ; Male ; Markov Chains ; Mass Screening - economics ; Medical sciences ; Medical screening ; Medical tests ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Nursing ; Original ; Original Article ; Patient Acceptance of Health Care ; Patient Compliance ; Prevention and actions ; Primary care ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Sensitivity analysis ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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Despite this recommendation, HIV testing rates are low even among those at identifiable risk, and many patients do not return to receive their results. Objective To examine the costs and benefits of strategies to improve HIV testing and receipt of results. Design Cost-effectiveness analysis based on a Markov model. Acceptance of testing, return rates, and related costs were derived from a randomized trial of 251 patients; long-term costs and health outcomes were derived from the literature. Setting/target population Primary-care patients with unknown HIV status. Interventions Comparison of three intervention models for HIV counseling and testing: Model A = traditional HIV counseling and testing; Model B = nurse-initiated routine screening with traditional HIV testing and counseling; Model C = nurse-initiated routine screening with rapid HIV testing and streamlined counseling. Main measures Life-years, quality-adjusted life-years (QALYs), costs and incremental cost-effectiveness. Key results Without consideration of the benefit from reduced HIV transmission, Model A resulted in per-patient lifetime discounted costs of $48,650 and benefits of 16.271 QALYs. Model B increased lifetime costs by $53 and benefits by 0.0013 QALYs (corresponding to 0.48 quality-adjusted life days). Model C cost $66 more than Model A with an increase of 0.0018 QALYs (0.66 quality-adjusted life days) and an incremental cost-effectiveness of $36,390/QALY. When we included the benefit from reduced HIV transmission, Model C cost $10,660/QALY relative to Model A. The cost-effectiveness of Model C was robust in sensitivity analyses. Conclusions In a primary-care population, nurse-initiated routine screening with rapid HIV testing and streamlined counseling increased rates of testing and receipt of test results and was cost-effective compared with traditional HIV testing strategies.</description><subject>Adult</subject><subject>Antiretroviral drugs</subject><subject>Biological and medical sciences</subject><subject>Cost control</subject><subject>Cost-Benefit Analysis</subject><subject>Economic analysis</subject><subject>General aspects</subject><subject>HIV</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - economics</subject><subject>HIV Infections - therapy</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Markov Chains</subject><subject>Mass Screening - economics</subject><subject>Medical sciences</subject><subject>Medical screening</subject><subject>Medical tests</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Nursing</subject><subject>Original</subject><subject>Original Article</subject><subject>Patient Acceptance of Health Care</subject><subject>Patient Compliance</subject><subject>Prevention and actions</subject><subject>Primary care</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Sensitivity analysis</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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Despite this recommendation, HIV testing rates are low even among those at identifiable risk, and many patients do not return to receive their results. Objective To examine the costs and benefits of strategies to improve HIV testing and receipt of results. Design Cost-effectiveness analysis based on a Markov model. Acceptance of testing, return rates, and related costs were derived from a randomized trial of 251 patients; long-term costs and health outcomes were derived from the literature. Setting/target population Primary-care patients with unknown HIV status. Interventions Comparison of three intervention models for HIV counseling and testing: Model A = traditional HIV counseling and testing; Model B = nurse-initiated routine screening with traditional HIV testing and counseling; Model C = nurse-initiated routine screening with rapid HIV testing and streamlined counseling. Main measures Life-years, quality-adjusted life-years (QALYs), costs and incremental cost-effectiveness. Key results Without consideration of the benefit from reduced HIV transmission, Model A resulted in per-patient lifetime discounted costs of $48,650 and benefits of 16.271 QALYs. Model B increased lifetime costs by $53 and benefits by 0.0013 QALYs (corresponding to 0.48 quality-adjusted life days). Model C cost $66 more than Model A with an increase of 0.0018 QALYs (0.66 quality-adjusted life days) and an incremental cost-effectiveness of $36,390/QALY. When we included the benefit from reduced HIV transmission, Model C cost $10,660/QALY relative to Model A. The cost-effectiveness of Model C was robust in sensitivity analyses. Conclusions In a primary-care population, nurse-initiated routine screening with rapid HIV testing and streamlined counseling increased rates of testing and receipt of test results and was cost-effective compared with traditional HIV testing strategies.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>20204538</pmid><doi>10.1007/s11606-010-1265-5</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Antiretroviral drugs
Biological and medical sciences
Cost control
Cost-Benefit Analysis
Economic analysis
General aspects
HIV
HIV Infections - diagnosis
HIV Infections - economics
HIV Infections - therapy
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Internal Medicine
Male
Markov Chains
Mass Screening - economics
Medical sciences
Medical screening
Medical tests
Medicine
Medicine & Public Health
Middle Aged
Nursing
Original
Original Article
Patient Acceptance of Health Care
Patient Compliance
Prevention and actions
Primary care
Public health. Hygiene
Public health. Hygiene-occupational medicine
Sensitivity analysis
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
title Cost-Effectiveness of Strategies to Improve HIV Testing and Receipt of Results: Economic Analysis of a Randomized Controlled Trial
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