Thyroid Hormone-Regulated Mouse Cerebral Cortex Genes Are Differentially Dependent on the Source of the Hormone: A Study in Monocarboxylate Transporter-8- and Deiodinase-2-Deficient Mice

Thyroid hormones influence brain development through the control of gene expression. The concentration of the active hormone T3 in the brain depends on T3 transport through the blood-brain barrier, mediated in part by the monocarboxylate transporter 8 (Mct8/MCT8) and the activity of type 2 deiodinas...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2010-05, Vol.151 (5), p.2381-2387
Hauptverfasser:	Morte, Beatriz, Ceballos, Ainhoa, Diez, Diego, Grijota-Martínez, Carmen, Dumitrescu, Alexandra M, Di Cosmo, Caterina, Galton, Valerie Anne, Refetoff, Samuel, Bernal, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antithyroid Agents - administration & dosage Biological and medical sciences Blood levels Blood-brain barrier Cerebral cortex Cerebral Cortex - embryology Cerebral Cortex - growth & development Cerebral Cortex - metabolism Deactivation Disruption DNA microarrays Female Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation, Developmental - drug effects Gene regulation Genes Hormones Hypothyroidism Hypothyroidism - genetics Inactivation Iodide peroxidase Iodide Peroxidase - deficiency Iodide Peroxidase - genetics Iodide Peroxidase - metabolism Iodothyronine Deiodinase Type II Male Membrane Transport Proteins - deficiency Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Methimazole - administration & dosage Mice Mice, Inbred C57BL Mice, Knockout Monocarboxylic Acid Transporters Oligonucleotide Array Sequence Analysis Pregnancy Reverse Transcriptase Polymerase Chain Reaction Symporters Thyroid Thyroid gland Thyroid hormones Thyroid Hormones - metabolism Thyroxine Thyroxine - metabolism Triiodothyronine Triiodothyronine - metabolism Vertebrates: endocrinology
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