Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and long-wavelength ultraviolet radiation (UVA)

Treatment of de-epithelialized human corneas with riboflavin (RF) + long-wavelength ultraviolet light (UVA; RFUVA) increases corneal stroma tensile strength significantly. RFUVA treatment retards the progression of keratoconus, perhaps by cross-linking of collagen molecules, but exact molecular mech...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2010-01, Vol.51 (1), p.129-138
Hauptverfasser:	McCall, A Scott, Kraft, Stefan, Edelhauser, Henry F, Kidder, George W, Lundquist, Richard R, Bradshaw, Helen E, Dedeic, Zinaida, Dionne, Megan J C, Clement, Ethan M, Conrad, Gary W
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Collagen - metabolism Corneal Stroma - drug effects Corneal Stroma - metabolism Deuterium Oxide - pharmacology Diacetyl - analysis Half-Life Magnetic Resonance Spectroscopy Photochemotherapy Photosensitizing Agents - administration & dosage Photosensitizing Agents - pharmacology Rabbits Riboflavin - administration & dosage Riboflavin - pharmacology Singlet Oxygen - metabolism Sodium Azide - pharmacology Squalus acanthias Tensile Strength Ultraviolet Rays
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