Depletion of DNMT3A Suppressed Cell Proliferation and Restored PTEN in Hepatocellular Carcinoma Cell

Promoter hypermethylation mediated by DNA methyltransferases (DNMTs) is the main reason for epigenetic inactivation of tumor suppressor genes (TSGs). Previous studies showed that DNMT1 and DNMT3B play an important role in CpG island methylation in tumorigenesis. Little is known about the role of DNM...

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Veröffentlicht in:	BioMed research international 2010-01, Vol.2010 (2010), p.1-10
Hauptverfasser:	Zhao, Zhujiang, Wu, Qingxiang, Cheng, Jian, Qiu, Xuemei, Zhang, Jianqiong, Fan, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Cancer Carcinoma, Hepatocellular - metabolism Cell Proliferation CpG Islands DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation Epigenetics Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Histocytochemistry Hospitals Humans Islands Kinases Life sciences Liver - metabolism Liver - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Promoter Regions, Genetic Proteins PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference Studies Tumor Cells, Cultured Tumors
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