Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers

The aim of the current study was to encapsulate celecoxib (Cxb) in the nanostructured lipid carrier (Cxb-NLC) nanoparticles and evaluate the lung disposition of nanoparticles following nebulization in Balb/c mice. Cxb-NLC nanoparticles were prepared with Cxb, Compritol, Miglyol and sodium taurochola...

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Veröffentlicht in:	Journal of controlled release 2010-06, Vol.144 (2), p.233-241
Hauptverfasser:	Patlolla, Ram R., Chougule, Mahavir, Patel, Apurva R., Jackson, Tanise, Tata, Prasad N.V., Singh, Mandip
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Animals Biological and medical sciences Biological Availability Celecoxib Chemistry, Pharmaceutical Dosage Forms Feasibility Studies General pharmacology Inhalation Lipids - administration & dosage Lung - metabolism Lung cancer Lung disposition Male Medical sciences Mice Mice, Inbred BALB C Nanoparticles - administration & dosage Nanostructured lipid carrier Nanostructures Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pyrazoles Sulfonamides
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