Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans

Abstract The role of the Alzheimer's Disease Neuroimaging Initiative Genetics Core is to facilitate the investigation of genetic influences on disease onset and trajectory as reflected in structural, functional, and molecular imaging changes; fluid biomarkers; and cognitive status. Major goals...

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Veröffentlicht in:	Alzheimer's & dementia 2010-05, Vol.6 (3), p.265-273
Hauptverfasser:	Saykin, Andrew J, Shen, Li, Foroud, Tatiana M, Potkin, Steven G, Swaminathan, Shanker, Kim, Sungeun, Risacher, Shannon L, Nho, Kwangsik, Huentelman, Matthew J, Craig, David W, Thompson, Paul M, Stein, Jason L, Moore, Jason H, Farrer, Lindsay A, Green, Robert C, Bertram, Lars, Jack, Clifford R, Weiner, Michael W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - diagnosis Alzheimer Disease - genetics Alzheimer's disease Alzheimer's Disease Neuroimaging Initiative (ADNI) Biological markers Biomarkers - cerebrospinal fluid Biomarkers - metabolism Blood Cerebrospinal fluid (CSF) Cognition Disorders - diagnosis Cognition Disorders - genetics Copy number variation (CNV) Diagnostic Imaging Disease Progression Fluorodeoxyglucose F18 Gene Expression Regulation - genetics Genetic factors Genetic Predisposition to Disease Genome-wide association studies (GWAS) Genome-Wide Association Study Genotype Humans Image Interpretation, Computer-Assisted - methods Magnetic resonance imaging (MRI) MicroRNAs - genetics Mild cognitive impairment (MCI) Monomeric Clathrin Assembly Proteins - genetics Mutation - genetics Neuroimaging Neurology Phenotype Phenotypes Radiopharmaceuticals
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