microRNA/Argonaute 2 regulates nonsense-mediated messenger RNA decay

Imperfect base‐pairing between microRNA (miRNA) and the 3′‐untranslated region of target messenger RNA (mRNA) triggers translational repression of the target mRNA. Here, we provide evidence that human Argonaute 2 targets cap‐binding protein (CBP)80/20‐bound mRNAs and exon junction complex‐bound mRNA...

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Veröffentlicht in:	EMBO reports 2010-05, Vol.11 (5), p.380-386
Hauptverfasser:	Choe, Junho, Cho, Hana, Lee, Hyung Chul, Kim, Yoon Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Adaptor Proteins, Signal Transducing - metabolism Ago2 Animals Argonaute Proteins Binding sites CBP80/20 Cell Line Codon, Nonsense - genetics Decay eIF4E EMBO31 EMBO36 Eukaryotic Initiation Factor-2 - metabolism Gene expression Gene Expression Regulation Humans Mammals microRNA MicroRNAs - metabolism Molecular biology NMD Nuclear Cap-Binding Protein Complex - metabolism Phosphoproteins - metabolism Protein Binding Protein Biosynthesis Ribonucleic acid RNA RNA Stability - genetics RNA, Messenger - metabolism RNA-Induced Silencing Complex - metabolism Scientific Report Scientific Reports
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