Effects of topical and subconjunctival bevacizumab in high-risk corneal transplant survival

To investigate whether corneal graft survival could be improved by topical or subconjunctival bevacizumab in a murine model of vascularized high-risk corneal transplantation. Before corneal transplantation, intrastromal sutures were placed for 2 weeks in the corneas of BALB/c mice, inducing intense...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2010-05, Vol.51 (5), p.2411-2417
Hauptverfasser:	Dastjerdi, Mohammad H, Saban, Daniel R, Okanobo, Andre, Nallasamy, Nambi, Sadrai, Zahra, Chauhan, Sunil K, Hajrasouliha, Amir R, Dana, Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Angiogenesis Inhibitors - administration & dosage Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal, Humanized Bevacizumab Conjunctiva Corneal Neovascularization - pathology Corneal Neovascularization - prevention & control Corneal Neovascularization - surgery Corneal Transplantation Disease Models, Animal Graft Survival - drug effects Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Risk Factors Transplantation, Homologous Vascular Endothelial Growth Factor A - antagonists & inhibitors
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