Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease
A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood.In the setting of excessive central adiposity,insulin resistance is the major underlying cause of fat accumulation in hepatocytes.Be...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2010-05, Vol.16 (18), p.2223-2226 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Basaranoglu, Metin Kayacetin, Serra Yilmaz, Nevin Kayacetin, Ertugrul Tarcin, Orhan Sonsuz, Abdullah |
| description | A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood.In the setting of excessive central adiposity,insulin resistance is the major underlying cause of fat accumulation in hepatocytes.Because of the difficulties with human trials,several animal models have been developed for this purpose mainly characterized as follows:genetically disturbed or murine fatty liver,methionine-choline deficient diet... |
| doi_str_mv | 10.3748/wjg.v16.i18.2223 |
| format | Article |
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| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2010-05, Vol.16 (18), p.2223-2226 |
| issn | 1007-9327 2219-2840 |
| language | eng |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Disease Models, Animal Energy Intake Fatty Liver - etiology Fatty Liver - metabolism Humans Insulin Resistance Lipid Peroxidation Mice Mitochondria, Liver - metabolism Obesity - complications Obesity - metabolism Oxidative Stress Rats Reactive Oxygen Species - metabolism Topic Highlight |
| title | Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease |
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