Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: Evidence supporting a mesothelial-to-epithelial transition

Abstract Objective Our objective was to characterize the expression and function of the miR-200 family of microRNAs (miRNA) in ovarian carcinogenesis. Methods We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets, the ZEB1 and ZEB2 transcriptional repressors, in...

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Veröffentlicht in:	Gynecologic oncology 2010-01, Vol.116 (1), p.117-125
Hauptverfasser:	Bendoraite, Ausra, Knouf, Emily C, Garg, Kavita S, Parkin, Rachael K, Kroh, Evan M, O'Briant, Kathy C, Ventura, Aviva P, Godwin, Andrew K, Karlan, Beth Y, Drescher, Charles W, Urban, Nicole, Knudsen, Beatrice S, Tewari, Muneesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Epithelial Cells - pathology Epithelium - pathology Feedback loop Female Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Humans Mesothelial MicroRNA MicroRNAs - biosynthesis MicroRNAs - genetics miR-200 Obstetrics and Gynecology Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Repressor Proteins - biosynthesis Repressor Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction Transcription Factors - biosynthesis Transcription Factors - genetics ZEB2 Zinc Finger E-box Binding Homeobox 2 Zinc Finger E-box-Binding Homeobox 1
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