Enhanced sensitivity to acute angiotensin II is testosterone dependent in adult male growth-restricted offspring

Placental insufficiency results in intrauterine growth restriction (IUGR) and hypertension in adult male growth-restricted rats. Although renal ANG II and plasma renin activity do not differ between growth-restricted and control rats, blockade of the renin-angiotensin system (RAS) abolishes hyperten...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2010-05, Vol.298 (5), p.R1421-R1427
Hauptverfasser:	Ojeda, Norma B, Royals, Thomas P, Black, Joshua T, Dasinger, John Henry, Johnson, Jeremy M, Alexander, Barbara T
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Angiotensin II - pharmacology Animals Birth Weight - physiology Blood pressure Blood Pressure - physiology Body Weight - physiology Drinking - physiology Female Fetal Growth Retardation - physiopathology Hypertension Hypertension, Renal - etiology Hypertension, Renal - physiopathology Kidney - anatomy & histology Kidney - physiology Male Orchiectomy Organ Size - physiology Phenylephrine - pharmacology Physiology Plasma Pregnancy Prenatal Exposure Delayed Effects - physiopathology Proteins Rats Rats, Sprague-Dawley Renin-Angiotensin System - drug effects Renin-Angiotensin System - physiology Rodents Sex Factors Testosterone Testosterone - blood Testosterone - physiology Vasoconstrictor Agents - pharmacology
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