A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats

Tissue macrophage inflammatory pathways contribute to obesity-associated insulin resistance. Here, we have examined the efficacy and mechanisms of action of a novel anti-inflammatory compound (HE3286) in vitro and in vivo. In primary murine macrophages, HE3286 attenuates LPS- and TNFalpha-stimulated...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2010-05, Vol.298 (5), p.E1036-E1048
Hauptverfasser:	Lu, Min, Patsouris, David, Li, Pingping, Flores-Riveros, Jaime, Frincke, James M, Watkins, Steve, Schenk, Simon, Olefsky, Jerrold M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Animals Blood Glucose - metabolism Blotting, Western Cell Movement - drug effects Chemical compounds Chemokines - metabolism Cytokines - metabolism Dehydroepiandrosterone - analogs & derivatives Dehydroepiandrosterone - pharmacology Diabetes Female Gene Expression Gluconeogenesis - drug effects Glucose Glucose Clamp Technique Glucose Tolerance Test Humans Immunohistochemistry Inflammation - drug therapy Inflammation - metabolism Insulin Resistance Lipids - blood Lipopolysaccharides Liver - drug effects Liver - metabolism Macrophages - drug effects Macrophages - metabolism Male Mice Middle Aged Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Obesity - drug therapy Obesity - metabolism Physiology Rats Rats, Zucker Rodents Tissues
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