Maternal Dioxin Exposure Combined with a Diet High in Fat Increases Mammary Cancer Incidence in Mice

Background: Results from previous studies have suggested that breast cancer risk correlates with total lifetime exposure to estrogens and that early-life 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure or diets high in fat can also increase cancer risk. Objectives: Because both TCDD and diet aff...

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Veröffentlicht in:	Environmental health perspectives 2010-05, Vol.118 (5), p.596-601
Hauptverfasser:	La Merrill, Michele, Harper, Rachel, Birnbaum, Linda S., Cardiff, Robert D., Threadgill, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases - genetics Biological and medical sciences Breast cancer Cancer Carcinogenesis Catechol O-Methyltransferase - genetics Cocarcinogenesis Cytochrome P-450 CYP1B1 Diagnosis Dietary Fats - administration & dosage Dietary Fats - adverse effects Dioxin Environment. Living conditions Environmental Pollutants - administration & dosage Environmental Pollutants - toxicity Estrogens Estrogens, Non-Steroidal - administration & dosage Estrogens, Non-Steroidal - toxicity Female Gene Expression - drug effects Gynecology. Andrology. Obstetrics Health aspects Humans Ketogenic diet Lesions Mammary gland diseases Mammary glands Mammary Neoplasms, Experimental - etiology Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - pathology Medical sciences Mice Polychlorinated Dibenzodioxins - administration & dosage Polychlorinated Dibenzodioxins - toxicity Pregnancy Prenatal Exposure Delayed Effects - etiology Public health. Hygiene Public health. Hygiene-occupational medicine Rats Risk Factors Toxicology Tumors Vehicles
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