B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

Lymphotoxin's role in prostate cancer progression In the early stages of prostate cancer, cancerous cell growth is dependent on androgens, hence the success of prostatectomy, radiation and androgen-ablating drug therapies. With time, the cancer often develops into an androgen-insensitive, thera...

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Veröffentlicht in:	Nature (London) 2010-03, Vol.464 (7286), p.302-305
Hauptverfasser:	Ammirante, Massimo, Luo, Jun-Li, Grivennikov, Sergei, Nedospasov, Sergei, Karin, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127/1220 631/250/1619/40 692/699/67/589/466 692/700/565/238 Androgens - metabolism Animals Apoptosis B-Lymphocytes - metabolism Bone marrow Development and progression Gene expression Health aspects Hormones, Sex Humanities and Social Sciences Humans I-kappa B Kinase - genetics I-kappa B Kinase - metabolism Infiltration letter Lymphocytes Lymphotoxin-alpha - metabolism Male Metastasis Mice multidisciplinary Orchiectomy Physiological aspects Prostate - metabolism Prostate - pathology Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms - physiopathology Rodents Science Science (multidisciplinary) Survival Analysis Tumors
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