The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

The lungs are generated by branching morphogenesis as a result of reciprocal signalling interactions between the epithelium and mesenchyme during development. Mutations that disrupt formation of either the correct number or shape of epithelial branches affect lung function. This, in turn, can lead t...

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Veröffentlicht in:	Human molecular genetics 2010-06, Vol.19 (11), p.2251-2267
Hauptverfasser:	Yates, Laura L., Schnatwinkel, Carsten, Murdoch, Jennifer N., Bogani, Debora, Formstone, Caroline J., Townsend, Stuart, Greenfield, Andy, Niswander, Lee A., Dean, Charlotte H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell Polarity - genetics Cell Polarity - physiology Chemotactic factors Congenital defects Cytoskeleton Data processing Development Endoderm Epithelium Fibroblast growth factor 10 Fibrosis Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Gestation Hypertension Hypoplasia Immunoblotting Immunohistochemistry Lung - embryology Lung diseases Mesenchyme Mice Models, Biological Molecular and cellular biology Morphogenesis Morphogenesis - genetics Morphogenesis - physiology Mutation Mutation - genetics Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Oligonucleotides - genetics Polarity Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, G-Protein-Coupled - physiology Respiratory Mucosa - embryology Respiratory Mucosa - metabolism Rho-associated kinase Saccule Signal transduction Signal Transduction - genetics
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