Redox regulation of DNA repair: implications for human health and cancer therapeutic development
Redox reactions are known to regulate many important cellular processes. In this review, we focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA repair proteins as well as indirect transcriptional regulation. A key player in the redox regulation of DNA repair...
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| Veröffentlicht in: | Antioxidants & redox signaling 2010-06, Vol.12 (11), p.1247-1269 |
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| container_title | Antioxidants & redox signaling |
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| creator | Luo, Meihua He, Hongzhen Kelley, Mark R Georgiadis, Millie M |
| description | Redox reactions are known to regulate many important cellular processes. In this review, we focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA repair proteins as well as indirect transcriptional regulation. A key player in the redox regulation of DNA repair is the base excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) in its role as a redox factor. APE1 is reduced by the general redox factor thioredoxin, and in turn reduces several important transcription factors that regulate expression of DNA repair proteins. Finally, we consider the potential for chemotherapeutic development through the modulation of APE1's redox activity and its impact on DNA repair. |
| doi_str_mv | 10.1089/ars.2009.2698 |
| format | Article |
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In this review, we focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA repair proteins as well as indirect transcriptional regulation. A key player in the redox regulation of DNA repair is the base excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) in its role as a redox factor. APE1 is reduced by the general redox factor thioredoxin, and in turn reduces several important transcription factors that regulate expression of DNA repair proteins. Finally, we consider the potential for chemotherapeutic development through the modulation of APE1's redox activity and its impact on DNA repair.</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Comprehensive Invited Reviews</subject><subject>DNA - genetics</subject><subject>DNA - metabolism</subject><subject>DNA Repair</subject><subject>DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism</subject><subject>Health</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Oxidation-reduction reaction</subject><issn>1523-0864</issn><issn>1557-7716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksuLFDEQxhtxcdfVo1cJeNhTz-bReXkQhvW1sCiInmMmXZmOdHfapHtx_3vTzqAuCJJDhapffUUVX1U9I3hDsNKXNuUNxVhvqNDqQXVGOJe1lEQ8XP-U1ViJ5rR6nPM3jDElBD-qTomWolGMnlVfP0Ebf6AE-6W3c4gjih69_rAtmcmG9BKFYeqD-1XKyMeEumWwI-rA9nOH7NgiZ0cHCc0dJDvBMgeHWriFPk4DjPOT6sTbPsPTYzyvvrx98_nqfX3z8d311famdpyTuWaKa9qAdIo2XjHNhXK6lZyUrRoHoJ2y2lPYCeoZ7Bj1mlIHrBVS7xST7Lx6ddCdlt0ArSujk-3NlMJg052JNpj7lTF0Zh9vDS33EVwXgYujQIrfF8izGUJ20Pd2hLhkIxuBFSsX_D_JGCdccFHIFwdyb3swYfSxjHYrbbaUCtxIwnihNv-gymthCC6O4EPJ32uoDw0uxZwT-N9rEmxWV5jiCrO6wqyuKPzzv2_zhz7agP0EuSqy4g</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Luo, Meihua</creator><creator>He, Hongzhen</creator><creator>Kelley, Mark R</creator><creator>Georgiadis, Millie M</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope><scope>5PM</scope></search><sort><creationdate>20100601</creationdate><title>Redox regulation of DNA repair: implications for human health and cancer therapeutic development</title><author>Luo, Meihua ; He, Hongzhen ; Kelley, Mark R ; Georgiadis, Millie M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-385924e7c824f839568c9d7516984cee9c8a9f2eb62f3eb32f922ce3d679b8373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Comprehensive Invited Reviews</topic><topic>DNA - genetics</topic><topic>DNA - metabolism</topic><topic>DNA Repair</topic><topic>DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism</topic><topic>Health</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Oxidation-Reduction</topic><topic>Oxidation-reduction reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Meihua</creatorcontrib><creatorcontrib>He, Hongzhen</creatorcontrib><creatorcontrib>Kelley, Mark R</creatorcontrib><creatorcontrib>Georgiadis, Millie M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antioxidants & redox signaling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Meihua</au><au>He, Hongzhen</au><au>Kelley, Mark R</au><au>Georgiadis, Millie M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Redox regulation of DNA repair: implications for human health and cancer therapeutic development</atitle><jtitle>Antioxidants & redox signaling</jtitle><addtitle>Antioxid Redox Signal</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>12</volume><issue>11</issue><spage>1247</spage><epage>1269</epage><pages>1247-1269</pages><issn>1523-0864</issn><eissn>1557-7716</eissn><abstract>Redox reactions are known to regulate many important cellular processes. 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| ispartof | Antioxidants & redox signaling, 2010-06, Vol.12 (11), p.1247-1269 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Care and treatment Comprehensive Invited Reviews DNA - genetics DNA - metabolism DNA Repair DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism Health Health aspects Humans Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Oxidation-Reduction Oxidation-reduction reaction |
| title | Redox regulation of DNA repair: implications for human health and cancer therapeutic development |
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