Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy

Temporal lobe epilepsy (TLE) is a condition characterized by an imbalance between excitation and inhibition in the temporal lobe. Hallmarks of this change are axon sprouting and accompanying synaptic reorganization in the temporal lobe. Synthetic and endogenous cannabinoids have variable therapeutic...

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Veröffentlicht in:	Experimental neurology 2010-06, Vol.223 (2), p.529-536
Hauptverfasser:	Bhaskaran, Muthu D., Smith, Bret N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anandamide Animals Anticonvulsants - pharmacology Arachidonic Acids - pharmacology Biological and medical sciences Cannabinoid Receptor Modulators - pharmacology Capsaicin - pharmacology Dentate Gyrus - drug effects Dentate Gyrus - physiology Disease Models, Animal Drug Design Endocannabinoid Endocannabinoids Epilepsy, Temporal Lobe - chemically induced Epilepsy, Temporal Lobe - drug therapy Epilepsy, Temporal Lobe - physiopathology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Male Medical sciences Mice Mice, Inbred Strains Mossy fiber sprouting Mossy Fibers, Hippocampal - drug effects Mossy Fibers, Hippocampal - physiology Muscarinic Agonists - toxicity Nervous system (semeiology, syndromes) Neurology Organ Culture Techniques Patch-Clamp Techniques Pilocarpine - toxicity Polyunsaturated Alkamides - pharmacology Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - physiology Seizure Sensory System Agents - pharmacology Synaptic Transmission - drug effects Synaptic Transmission - physiology TRPV Cation Channels - agonists TRPV Cation Channels - physiology Vanilloid VR1
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