Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

Hyper-IgE syndrome is an autosomal dominant immunodeficiency that has been linked to mutations in stat3 . This paper shows that stat3 mutant subjects fail to generate T H 17 cells, which may account for their susceptibility to recurrent infections. The autosomal dominant hyper-IgE syndrome (HIES, ‘J...

Ausführliche Beschreibung