Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance

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Veröffentlicht in:	Journal of Virology 2010-05, Vol.84 (10), p.5368-5378
Hauptverfasser:	NALAM, Madhavi N. L, ALI, Akbar, RANA, Tariq M, SCHIFFER, Celia A, ALTMAN, Michael D, KIRAN KUMAR REDDY, G. S, CHELLAPPAN, Sripriya, KAIRYS, Visvaldas, ZEN, Ayşegül Ö, HONG CAO, GILSON, Michael K, TIDOR, Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Catalytic Domain Crystallography, X-Ray Drug Design Drug Resistance, Viral Fundamental and applied biological sciences. Psychology HIV Protease - genetics HIV Protease - metabolism HIV Protease Inhibitors - chemical synthesis HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - metabolism HIV-1 - drug effects Human immunodeficiency virus 1 Humans Microbiology Miscellaneous Models, Molecular Protein Binding Protein Structure, Tertiary Structure-Activity Relationship Vaccines and Antiviral Agents Virology
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creator	NALAM, Madhavi N. L ALI, Akbar RANA, Tariq M SCHIFFER, Celia A ALTMAN, Michael D KIRAN KUMAR REDDY, G. S CHELLAPPAN, Sripriya KAIRYS, Visvaldas ZEN, Ayşegül Ö HONG CAO GILSON, Michael K TIDOR, Bruce
description	Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology. For an alternate route to JVI .asm.org, visit: JVI
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subjects	Biological and medical sciences Catalytic Domain Crystallography, X-Ray Drug Design Drug Resistance, Viral Fundamental and applied biological sciences. Psychology HIV Protease - genetics HIV Protease - metabolism HIV Protease Inhibitors - chemical synthesis HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - metabolism HIV-1 - drug effects Human immunodeficiency virus 1 Humans Microbiology Miscellaneous Models, Molecular Protein Binding Protein Structure, Tertiary Structure-Activity Relationship Vaccines and Antiviral Agents Virology
title	Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance
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